IN-VITRO SCREENING OF METHANOLIC LEAF EXTRACTS OF ALBAZIA SAMAN (Jacq.)Merr, FOR THEIR CYTOTOXIC ACTIVITY

Journal Title: Indo American Journal of Pharmaceutical Research - Year 2015, Vol 5, Issue

Abstract

The present study was designed to evaluate the invitro cytotoxic potential of methanolic extract of Albazia saman leaves. The extraction of leaves was carried out by Soxhlet apparatus using methanol. The Cytotoxicity of methanolic extract was tested by Brine shrimp lethality assay, Trypan blue dye exclusion method, Neutral red Cytotoxicity assay, MTT assay and Ethidium bromide – acridine orange staining. Studies have shown differential sensitivities to several natural compounds between tumor and normal cells in vitro and the results obtained from the present study show that the methanol extract from Albazia saman leaves to DLA cell lines, and L929 cell lines. Moreover it has protective effect against cancer by their effect on signal transduction in cell proliferation and angiogenesis. It also justifies the folklore medicinal uses and claims about the therapeutic values of this plant as curative agent against tumor and we therefore, suggest further, the purification and characterization of the phytochemicals along with investigations needed to provide some additional insight into the in vivo cytotoxicity activity of the plants with a view to obtaining useful chemotherapeutic agent. Hence the leaf extract is proved the herbal use of cytotoxic activity and it is recommended as anti-cancer drug further to isolate the bioactive compound and drug designing.

Authors and Affiliations

Keywords

Related Articles

ANTI-ARTHRITIC ACTIVITY OF PORTULACA OLARACEA L. SATIVA ON ANIMAL MODELS

The present study was designed to investigate anti-arthritic activity of Portulaca olaraceal. sativa leaves in rats. Arthritis was induced in rats in all groups of animals by injecting 0.05 ml of 0.5(w/v) suspension of k...

FORMULATION AND EVALUATION OF TOPICAL MICROSPONGE BASED GEL OF TURMERIC

A drug delivery system enables the introduction of a therapeutic substance in the body and improves its efficacy and safety by controlling the rate, time and place of release of drug in the body .One of these includes to...

PRESCRIBING PATTERN OF DRUGS IN PREGNANT WOMEN ATTENDING ANTENATAL OUTPATIENT DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL

Abstract Drug treatment during pregnancy presents a special concern. Pharmacoepidemiological studies can measure the extent of prescription and teratogenic drug use in pregnant women. Objective: To understand the prescri...

Formulation and Evaluation of Oro Dispersible Tablets of Famotidine using Superdisintegrants

The objective of the present investigation was to prepare oro dispersible tablets of Famotidine, because of their convenience in administration and suitability for patients having dysphagia. Tablets were prepared by dire...

FORMULATION AND EVALUATION OF AYURVEDIC HERBAL OIL

Abstract In India, the use of herbals for the purpose of beautification was found in the traditional literature medicine such as Ayurveda. Herbal cosmetics is one of the most potent and effective area of cosmetic technol...

Download PDF file
  • EP ID EP535694
  • DOI -
  • Views 106
  • Downloads 0

How To Cite

(2015). IN-VITRO SCREENING OF METHANOLIC LEAF EXTRACTS OF ALBAZIA SAMAN (Jacq.)Merr, FOR THEIR CYTOTOXIC ACTIVITY. Indo American Journal of Pharmaceutical Research, 5(), -. https://europub.co.uk./articles/-A-535694