In Vitro Studies of Some Medicinal Plants Extracts for Antiviral Activity against Rotavirus
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 2
Abstract
Every year, Rotavirus infection is responsible for over 600,000 childhood deaths worldwide, occurring mainly in developing countries in addition to infections of elderly people in nursing homes and compromised patients. In this study, we investigated in vitro antiviral activity of aqueous extracts of some medicinal plants including, garlic bulbs (Allium Sativum), ginger rhizomes (Zingiber officinale), pomegranate peel (Punica granatum ) and Lemongrass leaves (Cymbopogon citratus) against rotavirus. The study was carried out using multiple approaches both at cellular level using cell live MA-104 such as the Plaque assay which used for determining the quantity of infectious virus and the MTT test (3-4,5-dimethythiazol-2yl)-2,5- diphenyl tetrazolium bromide) to estimate the cytotoxicity of the tested plant extracts. The results showed that the dilutions of crude extracts of Allium sativum gave mean inhibition percentage for rotavirus of 73.33% while Zingiber officinale gave 68.33%, Cymbopogon citrates gave 67.33% and Punica granatum gave 65% inhibited. All plants extract showed antiviral activities but statistically no significant differences of antiviral activity were found among these plant extracts. These findings suggested that the anti-rotaviral activity might be owing to the presence of various compounds such as flavonoids, terpenes, polyphenolic derivatives and other compounds that have been documented to possess antiviral properties.
Authors and Affiliations
Zakia F. S. AL-Ballawi, Nezar A. Redhwan, Mohamed Ali 2
Keywords
Related Articles
- EP ID EP388542
- DOI 10.9790/3008-1202025358
- Views 85
- Downloads 0
Studies on Skin Sensitivity to Various Allergens in Jeddah, Saudi Arabia Using Skin Prick Test
Skin prick test is one of the more important diagnostic tests against allergic diseases, it uses a synthesized allergic extracts from different allergens. In this study skin prick test was done on 83 allergic persons and...
Effect of Hexavalent Chromium and Aluminium in Fresh Water Fish Ictalurus Punctatus and Bioremediation by Using Dead Fungal Biomass
Fish serum may reflect status of many biochemical processes in the metabolism. Heavy metals may alter serum biochemical parameters in fishes. In this study, the effect of Cr(VI) and Al(III) in fresh water fish I.Punctatu...
Using Salivary Analysis to Confirm the Presence of Metabolites
The deficiencies of current diagnostic tools for Addreall are analyzed. A Java-applet was developed which analyzes delta E values from the Color Catcherapp by TECHKON. This app is particularly useful for takingapictureof...
Effect of Methanolic Extract of Emilia Praetemissa on Paracetamol Induced Liver Damage in Albino Wistar Rats
The present investigation shows the hepato-protective role of Emilia praetermissa in paracetamolinduced liver toxicity. The study was conducted using forty Albino rats randomly divided into four groups of ten rats each....
Study of Air quality Status of some cities of Rajasthan
An attempt has been made in this investigation to ascertain air quality on major roads of Ajmer city in the form of Air Quality Index ( AQI). Monitoring stations were set up at fifteen strategic locations on all arterial...