In-vitro susceptibility of linezolid against methicillin resistant Staphylococcus aureus at a tertiary care hospital in Pakistan
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2013, Vol 3, Issue 4
Abstract
Objective: Methicillin resistant Staphylococcus aureus is a major nosocomial pathogen causing significant morbidity and mortality. The aim of this study was to evaluate the in vitro activity of linezolid against methicillin-resistant S. aureus. Methods: This was a descriptive study carried out at the Department of Microbiology, Army Medical College Rawalpindi from January to July 2010. The in vitro minimum inhibitory concentration of linezolid was determined against 74 strains of methicillin-resistant S. aureus by using the Epsilon- test (E-test) method (AB Biodisk, Sweden). Methicillin-resistant S. aureus was isolated from routine clinical specimens using standard microbiological procedures. Cefoxitin (30 μg) disk was used for detection of methicillin-resistant strains of Staphylococcus aureus. Results: Seventy-four isolates of methicillin-resistant S. aureus were obtained from various clinical samples. The majority of samples were from the pus followed by nasobronchial lavage, urine and vaginal swabs. All the isolates were highly susceptible to linezolid with minimum inhibitory concentration range of 0.023 - 0.75 mg/dL having MIC50 0.25 and MIC90 0.5 mg/dL respectively. Conclusion: Linezolid shows good in vitro activity against methicillin-resistant Staphylococcus aureus. J Microbiol Infect Dis 2013;3(4): 203-206 Keywords: Linezolid, methicillin resistance, minimum inhibitory concentration, Staphylococcus aureus, vancomycin.
Authors and Affiliations
Ali Khalid, Javaid Usman, Umaira Faiz, Fatima Kaleem, Afreenish Hassan, Maria Omair
Keywords
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- EP ID EP120789
- DOI 10.5799/ahinjs.02.2013.04.0109
- Views 135
- Downloads 0
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