In-vitro susceptibility of multiple drug resistant Pseudomonas aeruginosa to organic acids
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2013, Vol 3, Issue 2
Abstract
Objectives: Pseudomonas aeruginosa is a classic opportunistic pathogen with innate resistance to many antibiotics and disinfectants. Resistance to antimicrobial agents makes it the most noxious organism to eliminate from infection site. In view of its antimicrobial resistance, an attempt was made to study its susceptibility to various organic acids. Methods: Seven clinical isolates of P. aeruginosa resistant to multiple antibiotics were subjected to in vitro susceptibility to various organic acids by broth dilution method to find out susceptibility to various organic acids. Results: The isolates of P. aeruginosa resistant to 14 antimicrobials were found susceptible to one percent oxalic acid and trichloroacetic acid, two percent lactic acid and citric acid, and three percent acetic acid. It is interesting to note that strains resistant to multiple antibiotics were also found susceptible to organic acids. Oxalic acid and trichloroacetic acid were found highly effective. Conclusions: Clinical use of oxalic acid, trichloroacetic acid and lactic acid as topical agents to treat superficial pseudomonal infections caused by difficult strains of P. aeruginosa may be recommended after confirmation of their toxicity and in vivo efficacy in animal models. J Microbiol Infect Dis 2013; 3(2): 67-70 Key words: Pseudomonas aeruginosa, Multiple Antibiotic Resistance, Susceptibility to Organic Acids.
Authors and Affiliations
Basavraj S. Nagoba, Bharat J. Wadher, Sohan. P. Selkar
Keywords
Related Articles
- EP ID EP115172
- DOI 10.5799/ahinjs.02.2013.02.0083
- Views 118
- Downloads 0
Çin Guangdong Bölgesindeki bir üçüncü basamak hastanede izole karbapenem dirençli Enterobacteriaceae kökenlerinin moleküler özellikleri
Amaç: Bu çalışmada Çin’in Guangdong bölgesinde bulunan bir eğitim hastanesinde, Ocak 2008 ile Aralık 2011 tarihleri arasında dönemde izole edilen karbapenem dirençli Enterobacteriaceae (CRE), kökenlerinin moleküler özell...
Miliyer tüberküloz menenjit için ipucu olabilir mi? 25 erişkin miliyer tüberkülozlu menenjit olgusunun değerlendirilmesi
Amaç: Bu çalışmada, miliyer akciğer tüberkülozu (TB) olan ve olmayan tüberküloz menenjitli (TBM) olguların özelliklerinin karşılaştırılması amaçlanmıştır. Yöntemler: TBM’li 160 olgudan miliyer akciğer TB’si olan 25 olgu...
Crimean-Congo hemorrhagic fever and pregnancy: Two cases
Crimean-Congo Hemorrhagic Fever (CCHF) is a viral zoonosis, transmitted to humans by either: the Hyalomma species of ticks; or by direct contact with body fluids or tissues of infected humans or domestic animals. CCHF c...
Occupational exposures among healthcare workers: A teaching hospital sample
Objective: Healthcare workers (HCWs) are at risk for occupational injury associated with contaminated blood and body fluids. This study aims to examine the frequency and type of occupational injuries and to determine bes...
Kosova’da Bruselloz ve Kosova Üniversite Hastanesinde Bruselloz vakalarının klinik özellikleri
Amaç: Bruselloz Kosova’da dikkat çekici bir hastalık haline geldi. Ancak osova’dan bu hastalığın epidemiyolojisi ve klinik seyriyle ilgili kapsamlı bir çalışma ulunmamaktadır. Bu çalışma Kosova Üniversite Merkez Hastanes...