In vitro–In Vivo Correlations: Tricks and Traps
Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 3
Abstract
In vitro–in vivo correlation (IVIVC) is a biopharmaceutical tool recommended to be used in development of formulation. When validated, it can speed up development of formulation, be used to fix dissolution limits and also as surrogate of in vivo study. However, as do all tools, it presents limitations and traps. The aim of the present paper is to investigate five common traps which could limit either the setting or use of IVIVC (1) using mean or individual values; (2) correction of absolute bioavailability; (3) correction of lag time and time scaling; (4) flip-flop model; and (5) predictability corrections.
Authors and Affiliations
J. -M. Cardot, B. M. Davit
Keywords
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- EP ID EP681235
- DOI 10.1208/s12248-012-9359-0
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