IN-VIVO ANTI-TUMOR EFFECT OF 5-FLUOROURACIL LOADED CHITOSAN-SODIUM DEOXYCHOLATE NANOPARTICLES
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2019, Vol 5, Issue 2
Abstract
Chitosan- sodium deoxycholate nanoparticles containing 5-fluorouracil (5-FU) was prepared via a simple electrostatic interaction between oppositely charged particles using different weight ratios between chitosan and sodium deoxycholate. The objective of this work is to characterize and estimate the antitumor activity of the prepared chitosan- sodium deoxycholate nanoparticles loaded with 5-FU.The prepared nanoparticles were characterized in-vitro and in-vivo. The in-vitro characterizations were investigated by entrapment efficiency % (EE %), particle size analysis, zeta potential measurement, in-vitro release and Transmission Electron Microscopy (TEM). 5- FU loaded CS- DS nanoparticles showed EE% ranging from (14.54 ±1.35 to 22.43 ±2.12), reasonable mean particle sizes (165.65 ±17.23 to 318.47 ±25.86) and zeta potential (35.57 ±3.05 to 48.86 ±3.57 mV). The in-vitro release of nanoparticles exhibited an initial burst effect followed by a sustained drug release with approximately 90 % of the drug being released over 6 hrs. In-vivo anti-tumor effect was studied on solid ehrlich carcinoma (SEC) tumor bearing Swiss albino mice.The anti- tumor activity of 5-FU loaded in CS- DS nanoparticles was evaluated comparatively to control and plain formula. The results revealed that 5-FU loaded CS- DS nanoparticles effectively decreased tumor volume and showed significantly (p<0.05) lower tumor volume compared to control group and plain formula.
Authors and Affiliations
Ahmed Khairy
Keywords
Related Articles
- EP ID EP675275
- DOI -
- Views 184
- Downloads 0
A CRITICAL REVIEW STUDY ON TAMAK SHWASA (BRONCHIAL ASTHMA): AN AYURVEDIC PROSPECTIVE
Tamaka Shwasa is a very broad term which includes many more diseases where dyspnoea is predominant symptom. But still we can correlate Bronchial Asthma to Tamaka Shwasa, because out of the remaining four, three are incur...
FREQUENCY OF METABOLIC SYNDROME IN TYPE 2 DIABETES MELLITUS, SUDANESE POPULATION – WAD MEDANI-GEZIRA STATE-SUDAN- FEBRUARY 2015
Background: Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal (central) obesity, elevated blood pressure,...
PAIN MANAGEMENT IN PAEDIATRIC PRACTICE: THE VIEWS OF PAEDIATRIC HEALTH CARE PROVIDER ON THE USE OF ANALGESICS
Background: Pain remains a common event in paediatric practice. Whether brought on by disease, injury or a necessary procedure, alleviation of pain in children remains a topical issue, an area of continuing research and...
MODELLING ISOLATED SPINA BIFIDA SCREENING PERFORMANCE USING AXIAL AND SAGITTAL VIEWS OF THE BRAIN AND SPINE ANATOMY AT THE 11-13-WEEK SCAN
Objectives: The aim of this research is to evaluate the modeled predictive value of different features of the fetal anatomy in the detection of isolated open spina bifida, at first-trimester scan. Methods: We retrospecti...
DETERMINING THE QUALITY OF MANAGEMENT OF HEAD INJURY BY GENERAL SURGEONS
Background: Head injury is one of the common causes of surgical admission in DHQ hospital Sahiwal, Pakistan With no neurosurgeons available, most of the cases are managed effectively with adequately trained general surge...