In vivo Growth Kinetics of the Natural Course of an Undifferentiated Untreated Endometrial Cancer: An Observational Case Report
Journal Title: Journal of Andrology & Gynaecology - Year 2013, Vol 1, Issue 2
Abstract
We describe a patient with a histologically verified undifferentiated endometrial cancer who initially declined treatment, thus permitting study of the in vivo growth kinetics of the tumor. 266 days later, the patient was diagnosed with extensive symptomatic pelvic, abdominal, mediastinal, lung and supraclavicular metastases confirmed by imaging. During the untreated phase of 9.2 months, the tumor volume doubling time was estimated to be 56 + 3.5 (SD; standard deviation) days when an exponential tumor growth was assumed. This rapid growth was paralleled by immunohistochemistry showing a higher mitotic rate in the metastasis than in the primary tumor. At a late stage of the disease, laparotomy showed pelvic extension of the endometrial tumor, parenchymal liver metastasis and peritoneal carcinomatosis. The patient died 1.5 years after the initial diagnosis. To the authors´ knowledge, this is the first analysis of hypothetically generated exponential tumor kinetics of an untreated gynecological cancer in vivo. This report may serve as a reference for assessing future clinical interventions in endometrial cancer.
Authors and Affiliations
Edgar Petru
Laparoscopic Management of Leiomyoma Developing from Rudimentary Horn in Mayer- Rokitansky-Küster-Hauser Syndrome
Various congenital anomalies of the mullerian system have so far, been described. Our case with MRKH syndrome had two rudimentary horns, and had also a leiomyoma arising from the left rudimentary horn. The patient was pr...
Association of the Force of Ejaculation and Orgasm Satisfaction using Novel Assessment Tools: Prospective Trial in Healthy Men
Background: Orgasmic and ejaculatory disorders affect hundreds of thousands of men worldwide, but remain poorly understood and studied. No validated and reproducible tools are available to assess orgasmic satisfaction. I...
Semen Quality of Male Partners of Infertile Couples Attending Fertility Clinics in Delta State University Teaching Hospital, Oghara, Delta State, Nigeria
Objective: To determine the proportion of sperm concentration abnormality, teratozoospermia index and the nature of semen abnormal parameters seen among male partners of infertile couples. Materials and methods: This is...
The Effects of Varicocele on DNA Morphology
Varicocele is one of the major causes of infertility in men. Although there are different theories related to the pathophysiology of the varicocele, the exact pathophysiologic mechanism remains unknown. Sperm DNA damage...
Management of Endometriosis- Associated Infertility
Endometriosis is a common, chronic disease. Patients typically present with pelvic pain, infertility, and/or an adnexal mass. Results from the limited number of studies that have been published indicate that the true pre...