IN-VIVO PHARMACOKINETIC STUDIES OF SOLID DISPERSIONS OF CELECOXIB
Journal Title: International Journal of Pharmacy and Technology - Year 2010, Vol 2, Issue 2
Abstract
Dissolution rate and dissolution efficiency of poorly soluble non-steroidal anti inflammatory drugs (NSAIDs) could be markedly enhanced by solid dispersion technology. Solid dispersions of celecoxib (C) are subjected to in vivo pharmacokinetic evaluation to evaluate whether these systems improve oral bio availability of the celecoxib. All the pharmacokinetic parameters of absorption, namely Ka, Cmax, Tmax, percent absorbed to various times and AUC indicated rapid absorption and higher bioavailability of celecoxib when administered as its solid dispersions. The absorption rate constant (Ka) was found to be 3.5526hr-1 in the case of celecoxib-Croscarmellose-Poly venyl pyrrolidine (C-CC-PVP) solid dispersion. Where as in the case of celecoxib Ka was only 0.412 hr-1. An increase of 8.6 fold in Ka was observed with celecoxib-CC-PVP solid dispersion. AUC (extent of absorption) was also much higher in the case of celecoxib -CC-PVP solid dispersion when compared to celecoxib. [AUC]0-12h was increased from 91.54 ng-hr/ml for celecoxib to 587.13 nghr/ml for celecoxib-CC-PVP solid dispersion . Both Ka and AUC were markedly increased by CCPVP solid dispersion . Thus, the results of pharmacokinetic studies indicated rapid and higher oral absorption of celecoxib when administered as CC-PVP solid dispersion.
Authors and Affiliations
Prof. Nagabhushanam
Keywords
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