IN VIVO PROTON MR SPECTROSCOPY IN DIAGNOSIS OF INTRACRANIAL CYSTIC LESIONS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 19
Abstract
BACKGROUND Magnetic resonance spectroscopy (MRS)1 is a non-invasive diagnostic tool that has been used to detect biochemical environment and the concentration of the metabolites in various tissues, which correlate with physiologic and pathological processes. Aims and Objectives: To determine the use of proton in vivo spectroscopy in diagnosing intracranial cystic lesions by providing additional metabolic information. MATERIALS AND METHODS This is a retrospective, descriptive, single institutional study with study population of 108 patients with intracranial cystic lesions. 1.5 Tesla Siemens system was used to perform MRI brain conventional sequences along with MR spectroscopy. RESULTS The pyogenic abscess showed amino acids, alanine, lactate, lipid and acetate peaks. Tuberculous abscess showed tall lipid with lactate peak and absent amino acids. Both neurocysticercosis and hydatid cysts showed succinate and lactate peaks with minimal acetate along with creatinine peak in NCC. Lactate was found in the benign non-neoplastic cysts studied including arachnoid cysts, porencephalic cysts, epidermoid cysts, craniopharyngioma and DNET. While choroid fissural cyst, choroid plexus cysts, ganglioglioma showed no specific metabolite. One colloid cyst studied showed increased NAA peak at 2.0 ppm. Among the malignant lesions, high-grade tumours showed lipid peak in addition to increased choline, lactate peaks, decreased creatinine and NAA peak. Metastatic lesions showed lipid and lactate peaks. CONCLUSION Magnetic resonance spectroscopy has a definitive complementary role in aiding the diagnosis of various intracranial cystic lesions.
Authors and Affiliations
Sukumar Ramasamy, Periakaruppan Alagappan, Amarnath Chellathurai, Priya Muthaiyan, Suja Rajan
Keywords
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- EP ID EP418263
- DOI 10.14260/jemds/2018/540
- Views 101
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