Increased Survival after Treatment of Canine Hemangiosarcoma with Fenofibrate
Journal Title: International Journal of Veterinary Science and Research - Year 2015, Vol 1, Issue 1
Abstract
Hemangiosarcoma (HSA) is a common and highly metastatic tumor that affects predominantly large-breed dogs. The median survival time for dogs diagnosed with splenic HSA without adjuvant chemotherapy after surgery is 86 days. Fenofibrate is an FDA-approved drug commonly utilized to treat high cholesterol and high triglyceride levels in humans. However, fenofibrate has also been shown to possess anti-proliferative and anti-metastatic properties against several aggressive and highly metastatic tumors in vitro and in small animal models. We report a case of a 6.5-year-old dog diagnosed with a splenic hemangiosarcoma and treated solely with micronized fenofibrate, administered orally once a day following splenectomy. The dog survived for over 26 months (804 days) after initial diagnosis without signs of adverse effects due to fenofibrate treatment.
Authors and Affiliations
Ecke Johanna K, Valle Luis Del, Struckhoff Amanda Parker, Reiss Krzysztof, Peruzzi Francesca
Keywords
Related Articles
- EP ID EP553768
- DOI 10.17352/ijvsr.000003
- Views 51
- Downloads 0
Increased Survival after Treatment of Canine Hemangiosarcoma with Fenofibrate
Hemangiosarcoma (HSA) is a common and highly metastatic tumor that affects predominantly large-breed dogs. The median survival time for dogs diagnosed with splenic HSA without adjuvant chemotherapy after surgery is 86 da...
Freshwater Snail Distribution Related to Physicochemical Parameters and Aquatic Macrophytes in Giza and Kafr El-Shiekh Governorates, Egypt
A field work was conducted to study the density of the freshwater snail in relation to the vegetation cover as well as the physical and chemical properties in different watercourses. Two sites were selected in Giza gover...
Study on Effect of Diatomaceous Earth (DAE) on Aflatoxin-Induced DNA Damage in Visceral and Lymphoid Organs in Broiler Chicken
Background: Limited information exists concerning on the effect of diatomaceous earth (DAE) on aflatoxin-induced DNA damage in visceral and lymphoid organs. Objectives: The present investigation is an attempt to detect...
Bovine Genital Campylobacteriosis - A Review
Bovine genital campylobacteriosis (BGC) is a true venereal disease of cattle. This disease results in infertility, embryonic and fetal death, metritis, salpingitis, pyometra, and abortion in cattle, and sheep and goats a...
Functional Properties (Acid and Bile Tolerance) and Antibiotic Susceptibility of Lactic Acid Bacteria Isolated from Newborn Calves for the Design of a Probiotic Product
Diarrhea in young calves in dairy farms is one of the main causes of economic losses, morbidity and mortality. The use of probiotic products as feed additives or complements is a novel alternative for the prevention of i...