Increasing the Probability of Discovering Improved Antiepileptic Drugs through the Use of Human Epileptic Tissue
Journal Title: Archives of Pharmacy & Pharmacology Research - Year 2018, Vol 1, Issue 2
Abstract
Epilepsy affects millions of people world-wide with wide-ranging health and economic consequences [1]. A first-line approach to the control of epilepsy is through the administration of anticonvulsant drugs sometimes referred to as antiepileptics [2]. These medicines help control seizure activity but the evidence for controlling disease progression in patients is not firmly established [3]. There are many antiepileptics approved for clinical use [2] that dampen excitatory neurotransmission through different mechanisms including positive allosteric modulation of GABA (e.g., diazepam, valproic acid) and blockade of ion channels (e.g., gabapentin, lacosamide).
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- EP ID EP593839
- DOI 10.33552/APPR.2018.01.000510
- Views 63
- Downloads 0
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