Increasing The TNF - α Lev els In Nasal Lavage Liquid And Pulmonary Function D ecrease Of Rice Mill Operator E xposed To Lipopolysaccharide (LPS ) Endotoxin
Journal Title: International Journal of Scientific Research and Management - Year 2015, Vol 3, Issue 7
Abstract
Background: Exposure to endotoxin lipopolysaccharid e in rice dust causes the inflammationinrespiratory tractwhich is characterized by an increase in Tumor Necrosis Factor Alpha (TNF - α) as well as the decline in pulmonary function of the rice mill operators. Objective: The aim of this study was to analyze t he correlated of endotoxin LPS to increased levels of TNF - α in nasal lavage liquid and pulmonary function decline of the rice mill operators. Methods: This study was designed as a prospective longitudi nal study.Dust sampling conducted during 8 hourswhile s ampling the nasal lavage fluid and pulmonary function measurements made before and after the work (cross shift). Levels of TNF - α and endotoxin LPS subsequently analyzed using ELISA method, afterwards LPS analyzed by LAL method. Pulmonary function was analy zed by spirometry. Results: The mean levels of endotoxin LPS in the dust of ricewas 56.36±5.83 EU/m3. There are enhancement in the levels of TNF - α after the work (paired - samples t test:p=0.000) in which TNF - α levels increased in all rice mill operator afte r work. FVC decline of 72.73% and 63.64% for FEV1. Pulmonary function status after the work is: normal =36.36%, obstruction and restriction =36.36% =27.27%. Level of LPS endotoxin correlated to the increase in TNF - α in nasal lavage fluid workers (multiple linear regression test:p =0.000). Endotoxin LPS correlated tothe value ΔFVC and ΔFEV1 (multiple linear regression test:p <0.05). Conclusion: Endotoxin lipopolysaccharide is a factor affecting the increase in TNF - α level in nasal lavage fluid and pulmonary function decline rice mill operator. Suggestion: Please use a rice Mill machine equipped with a dust collector. Need periodic medical examination and treatment and rest or rolling work for workers who experience respiratory problems. Workers are advised to always using masks while working
Authors and Affiliations
William Wilfridus Lamawuran
Keywords
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