Indicators of nitrosative and oxidative stress as non-invasive markers of bacterial meningitis in preterm infants
Journal Title: Здоров`я дитини - Year 2019, Vol 14, Issue 3
Abstract
Background. In oxidative and nitrosative stresses, the brain is vulnerable to oxidant damage due to high oxygen consumption, large amounts of iron, relatively low antioxidant expression, high concentration of polyunsaturated fatty acids. One of the markers of nitrosative stress is nitrotyrosine. Cerebrospinal fluid high concentration of nitrotyrosine is associated with the adverse course of the disease. Homocysteine is also considered as an indicator of the intensity of oxidative stress. Increased concentrations of homocysteine have cytotoxic effects that leads to cell death. Materials and methods. The study included 52 preterm infants. The basic group consisted of 14 preterm infants (mean gestation period 31.7 ± 0.9 weeks) with bacterial meningitis. The experimental group included 20 newborns with the perinatal disorders of the central nervous system (10 preterm infants with an average gestational age of 32.3 ± 0.4 weeks and 10 full-term newborns). Control group consisted of full-term healthy 18 newborns. Anamnesis, somatic and neurological status of newborns, neurosonography data were evaluated. The nitrotyrosine blood serum concentration was evaluated using enzyme-linked immunosorbent assay. Results. The results of the study demonstrated that nitrotyrosine content in the blood serum of newborns in the basic group was significantly lower than in the experimental and control groups (1.38 ± 0.06 vs 1.53 ± 0.07 and 1.61 ± 0.04 mmol/L, respectively, p < 0.05) and depended on the gestational age of a child (r = +0.63; p < 0.05). The homocysteine level in blood serum had an inverse correlation with a gestational age of the child (r = –0.62; p < 0.05) and in newborns in the main group statistically exceeded the rates of newborns in the experimental group and the control group (17.10 ± 1.13 versus 10.80 ± 1.10 and 9.56 ± 1.42 μmol/L, respectively; p < 0.05). Conclusions. Low levels of nitrotyrosine in serum and hyperhomocysteinemia observed in preterm infants may contribute to damage to the vascular bed, penetration of microorganisms through the blood-brain barrier and the development of the infectious process. The maximum content of homocysteine in blood serum is observed with the development of bacterial meningitis.
Authors and Affiliations
G. O. Lezhenko, O. Ye. Pashkova, A. V. Abramov, L. O. Volotko
Keywords
Related Articles
- EP ID EP577074
- DOI 10.22141/2224-0551.14.3.2019.168765
- Views 100
- Downloads 0
Features of Antibiotic Therapy for Respiratory Infections in Children
The paper presents an algorithm for the empirical selection of antibiotics in the treatment of acute respiratory infections in children, depending on the characteristics of their modern etiological structure and resistan...
The choice of an antibacterial drug for urinary infections treatment in children
Infections of the urinary system in childhood take the second place in the frequency of visits for primary medical care. Escherichia coli is the most causative agent of community-acquired forms of infections of the urina...
Correction of Asthenoneurotic Manifestations in Children with Primary Hypertension on the Background of Noophen Administration
The article deals with the use of the drug Noophen in the combination treatment of children with psycho-vegetative syndrome and labile hypertension. Consequently, the study found that Noophen in combination with non-drug...
Gastrointestinal symptoms in children with acute neuroinfections
Background. In cases of severe forms of infectious diseases, in addition to local inflammation, secondary lesions of the gastrointestinal organs may occur. We aimed to study the semiotics and epidemiology of gastrointes...
Do not Overlook a Diagnosis, Doctor!
Some diseases, especially at the early stage of their development, mimic infectious diseases. This is mainly due to the nonspecific character of the symptoms that characterize the initial manifestations of intoxication s...