INDIGENOUS EFFECT OF CYNODON DACTYLON IN EXPERIMENTAL INDUCED ULCERS AND GASTRIC SECRETIONS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
Cynodon dactylon is a perinneal grass,the plant is a rich source of metabolites such as proteins,carbohydrates mineral constituents, β-sitosterols, flavinoids, alkaloids, glycosides and triterpenoids the plant has been long used in traditional medicines to treat various alignments it also has antiviral and antimicrobial properties but none has proved its efficacy in evaluating gastro protective activity so we had made an attempt to evaluate the gastroprotective effect of extract of Cynodon dactylon in albino rats. The experiment was set up using male albino wistar rats weighing 150-180gms. These were further divided evenly into different treatment groups. The extract of Cynodon dactylon was investigated for its anti- ulcer activity against pylorus ligation, aspirin induced and ethanol induced gastric ulcer in rats at 100,200, 300mg/kg body weight. Histopathological assessment of rat stomach was carried out. A significant reduction (p<0.01) in ulcer index was seen in Cynodon dactylon extract treated rats of pylorus ligation, aspirin induced and ethanol induced gastric ulcer models. The gastroprotective effect was further confirmed by histopathological examination of rat stomach. Thus the present study concludes the Cynodon dactylon extract having potential gastroprotective effect in the three models tested.
Authors and Affiliations
Suresh Kondaveeti , Anand Ivvala , Kumaraswamy Dabburu , Saleem Basha, Sailaja Inampudi
Keywords
Related Articles
- EP ID EP145691
- DOI -
- Views 123
- Downloads 0
ETHNOPHARMACOLOGICAL POTENTIAL OF CALOTROPIS PROCERA: AN OVERVIEW
The herbal medicine occupy distinct position right from ancient period. The plant Calotropis procera is known by different names in different part of the world. It is a wild growing medicinal plant distributed throughou...
FORMULATION DEVELOPMENT AND EVALUATION OF TERBUTALINE SULPHATE MUCOADHESIVE BUCCAL TABLETS
The main objective of developing any new dosage form is reduce the side effects and increase the therapeutic effect of drug in existing dose of dosage form. Mucoadhesive drug delivery system is oral dosage form, where th...
A RANDOMISED CLINICAL TRIAL COMPARING THE EFFICACY OF OXYTOCIN INJECTION AND ORAL MISOPROSTOL TABLET IN THE PREVENTION OF POSTPARTUM HAEMORRHAGE IN MAIDUGURI NIGERIA
To compare the effectiveness of intravenous oxytocin 10 IU and oral misoprostol tablet 600ug in the prevention of PPH. A randomised approach was used to recruit 1800 consenting pregnant women whom were randomly allocated...
TRACHYSPERMUM AMMI (AJWAIN): A COMPREHENSIVE REVIEW
The use of plants as medicine is as old as human civilization. People of all ages in both developing and developed countries use plants in an attempt to cure various diseases and to get relief from physical sufferings. N...
A WAY TO INCREASE EFFECTIVENESS OF PARACETAMOL DRUG THROUGH TRANSDERMAL PATCH
Millions of people around the world suffers from the fever, effective treatment is essential by formulating Transdermal patch. Paracetamol IP traditionally considered as a NSAID, is an effective analgesic and antipyretic...