Inflammation and Its Association with Appetite and Quality of Life of Patients on Maintenance Hemodialysis
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 7
Abstract
A study was conducted to evaluate the inflammatory status in maintenance hemodialysis (MHD) patients and correlate with self reported appetite and their health related quality of life. Ninety patients on MHD for 6 months and above (56 males and 34 females; mean age 52.6±11.7 years; mean dialysis vintage 20.99 ± 12.08 months) were studied. Serum inflammatory markers TNF-α and hs CRP, self reported appetite using Appetite and Diet Assessment Tool and health related quality of life by Health survey for dialysis patients – Short form 36 (SF 36) were assessed. The mean serum TNF-α and hs CRP levels were 39.798 ±15.19 pg/mL and 10.158 ± 2.82 mg/L respectively. Appetite was very good for 14.4% patients, good and fair for 47.8%, poor and very poor for 37.8% patients. Poorer the appetite significantly higher was the TNF- α and hs CRP levels (P < 0.0001). The mean score of total physical component of the QOL was 40.64± 10.8, total mental component was 37.56 ± 13.2 and the mean overall QOL score was 39.0 ± 11.9. TNF – α had a highly significant negative correlation with total physical component (r= -0.713; P< 0.0001), total mental component (r= -0.727; P< 0.0001), and overall quality of life scores (r= -0.735; P< 0.0001). Similarly hs CRP also had a highly significant negative correlation with total physical component (r= -0.481; P< 0.0001), total mental component (r= -0.515; P< 0.0001), and overall quality of life (r= - 0.508; P< 0.0001). Poorer the appetite lower were the mean QOL scores. Patients on MHD suffer an inflammatory state which is strongly associated to anorexia and poor quality of life. Interventions to decrease inflammation may improve appetite and health related quality of life of these patients
Authors and Affiliations
N. Vanitha Rani
Keywords
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