Inflammatory Myofibroblastic Tumour –An Unusual Tumour with Intermediate Malignant Potential- Report of Three Cases
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 12
Abstract
Inflammatory Myofibroblastic Tumour (IMT) is a rare mesenchymal neoplasm of borderline malignancy. It is characterised by proliferation of myofibroblasts and fibroblasts with variable amount of inflammatory infiltrate. About 50-60% of the cases show Anaplastic Lymphoma Kinase (ALK) rearrangements. The recurrence rate and metastasis depends on the anatomic site, resectability, size and presence of ALK rearrangements. In this case series, we are presenting three cases diagnosed as IMT. All the patients were elderly. Sites included abdomen, subcutaneous tissue over scapula and orbit. Scapular lesion presented as recurrence in six months after first excision. All three cases were ALK negative. IMTs that occur in elderly persons can mimic malignancy. Surgical excision is the treatment of choice. Diagnosis depends on histopathological features and immunohistochemical examination. Correct histological diagnosis is crucial for further management. Chance of recurrence and metastasis is more in abdominopelvic location, large size and ALK negativity. This case series aims to create awareness of the non-specific presentation of this tumour and need of follow up as this tumour may recur in a very short interval.
Authors and Affiliations
Dr. Indusarath, Sangeetha K Nayanar, Nizamudheen M Pareekutty, B Satheesan, Satheesh Babu
Keywords
Related Articles
- EP ID EP367584
- DOI 10.7860/JCDR/2017/32212.11008
- Views 50
- Downloads 0
CDX-2 Protein Expression in Premalignant and Malignant Lesions of Gallbladder
ABSTRACT Introduction: CDX2 is a caudal type homeobox gene encoding a transcription factor that play important role in regulating proliferation and differentiation of the intestinal epithelium. Recent studies demonstrat...
Role of TNF-α on the Function of Erythropoietin and Haematological Profile in Pulmonary Tuberculosis Patients
ABSTRACT Introduction: Pulmonary Tuberculosis (PTB) is one of the major causes for morbidity and mortality to the mankind and India accounts for over one fourth of global Tuberculosis (TB) burden. In PTB, the expression...
Impact of Nano Hydroxyapatite, Nano Silver Fluoride and Sodium Fluoride Varnish on Primary Teeth Enamel Remineralization: An In Vitro Study
Introduction: Dental caries is still prevailing worldwide, although different anti caries products have been introduced. Each remineralizing agent has its own shortcomings. Therefore, looking for new agents to have benef...
Osseous Metaplasia of Juvenile Polyp
ABSTRACT Bone formation in the gastrointestinal tract is very uncommon. We came across a case of 12-year-old boy with rectal bleeding because of rectal polyp. Snare resection of that polyp was done, and pathology report...
RCT on the Effect of Dexmedetomidine as an Adjuvant to Ropivacaine in Ultrasound Guided Fascia Iliaca Block for Postoperative Analgesia Following Hemi-Arthroplasty
ABSTRACT Introduction: Fascia Iliaca Compartment Block (FICB) has been employed for post-operative pain relief after hip surgeries. Dexmedetomidine has been found to prolong effect of peripheral nerve blocks but its effe...