INFLUENCE OF BACTERIOPHAGE DRUGS ON THE PROCESS FILMFORMATION STAPHYLOCOCCUS AUREUS STRAINS
Journal Title: Наукові доповіді НУБіП України - Year 2017, Vol 3, Issue 3
Abstract
High level of resistance to antibiotics of bacteria in biofilms causes an actuality of finding of additional preparates for treatment of infections caused by film-forming bacteria. As one of the same preparations are bacteriophages. Maximal efficacy of inhibition of film growth was during use of piobactariophage polyvalent. Significant changes were fixed during it use on daily biofilm. It was shown that decrease of: amond of CFU in plankton in 115.00 ± 5.44 times, amond of CFU in biofilm – in 63.90 ± 2.10 times, dry weight of biofilms – on 34.47 ± 5.29%, conteine of matrix protein – on 41.77 ± 7.14%, and optical density of biofilms – on 47.27 ± 10.24% compared to control of 2 day biofilm. Minimal efficacy took place during bacteriophage staphylococcal liquid action. It maximal effect took place during addition of this preparate on 2 day biofilm. It was shown a decrease of planktonic CFU in 83.17 ± 3.55 times, CFU in biofilm in 62.20 ± 3.04 times, dry weight of biofilms – on 32.67 ± 5.75%, contein of matrix protein – on 37.17 ± 3.53%, and optical density of biofilms – on 42.67 ± 7.47% compared to 3 day biofilm. Given data can make a conclusion the bacteriophages may have great place for medicine and agriculture for reduce of use of antibiotics.
Authors and Affiliations
E. S. Vorobey, O. S. Voronkova, A. I. Vinnikov
Keywords
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