Influence of glycaemic control on platelet count in type II diabetics in absence of vascular complications
Journal Title: Medpulse International Journal of Physiology - Year 2018, Vol 5, Issue 2
Abstract
Background: Diabetes mellitus (DM) has attained a state of a global emergency with increasing prevalence worldwide. Altered thrombocyte morphology, count and function have been reported with diabetics. The present study aimed at determining the variation in platelet count with degree of glycaemic control in Type 2 diabetes patients. Methods: A total of 200 subjects were enrolled in the study of which 100 had HbA1c < 6.5 and 100 had HbA1c > 6.5. Sample for glucose estimation and platelet indices were collected and estimation were carried out by the auto-analyzer. The statistical evaluation was done using SPSS version 22. Student t- test was used for comparison between two variables namely HbA1c and platelet count. Results: Mean Platelet count was found to be significantly higher in patients with type -2 diabetes mellitus with HbA1C > 6.5 in comparison to patients having HbA1c < 6.5.(p < 0.01) Conclusion: This study revealed a higher mean platelet count for diabetics with poor glycaemic control than for diabetics with good glycaemic control. However, platelet counts in both groups were within the normal reference range for healthy individuals. Platelet count with other platelet indices like Mean Platelet Volume and Platelet Distribution Width are simple, effective and cheap tests that may be used to predict vascular complications in type 2 DM.
Authors and Affiliations
Kazi Husna Abdul Naeem, Mohammed Abdul Hannan Hazari, Farisa Khatoon, Farah Bahmed, Fariha Mohammedi
Keywords
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