Influence of Hepatitis B and Hepatitis C Virus Infections and Human Immunodeficiency Virus Therapy on Liver Status of Patients with Human Immunodeficiency Virus
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 11, Issue 7
Abstract
Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are emerging among Human Immunodeficiency Virus (HIV) patients. Aim: To determine the impact of the presence of hepatitis B and hepatitis C viral infections as well HIV treatment on the liver of patients with HBV, HCV and HIV co-infections. Methods: A descriptive, cross-sectional study on 115 HIV patients that were subdivided into two groups; group A included 67 patients who had HIV mono-infection and group B included 48 patients who had HIV plus HBV, HIV plus HCV or HIV plus both. Results: 48 HIV patients (41.7%) had HBV and/or HCV infections. 4 patients (3.5%) were positive for HBV Surface Antigen (HBsAg), 37 patients (32.2%) were positive for HCV Anti-body (Anti-HCV Ab) and 7 patients (6.1%) were positive for both. HIV treatment caused significant impairment of liver functions especially in group B patients. CD4+ T Lymphocytes significantly increased after HIV therapy in group A versus group B. Conclusion: HIV may accelerate liver damage caused by HBV and HCV. HIV therapy carries a potential risk for hepatotoxicity.
Authors and Affiliations
Tary Abdel-Hamid Salman, Khaled Mohammad Attallah, Omkolsom Mohamed EL-Haddad, Azza Mohamed Abdel-Latif, Mohamed Abdou Awid
Keywords
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- EP ID EP340163
- DOI 10.9734/BJMMR/2016/19183
- Views 54
- Downloads 0
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