Influence of hydrophilic and hydrophobic polymers on controlled release of propranolol hydrochloride from matrix tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 2
Abstract
In the present investigation Propranolol HCl was employed in the controlled drug delivery system for extending the drug release for a prolonged period of time. Propranolol hydrochloride is a non-selective beta blocker used in the treatment of hypertension. It is soluble in water, methanol and chloroform. Propranolol is well absorbed from the gastrointestinal tract. The absolute bioavailability of an oral dose of an immediate- release formulation (compared to intravenous administration) is approximately 40%. Propranolol is 70% to 80% bound to plasma proteins. The plasma elimination half-life of Propranolol is approximately 3.0 to 4.5 h. Only 2% to 4% of unchanged Propranolol appears in the urine. The major drug is excreted through renal and biliary excretion. Based on the biopharmaceutical properties the drug Propranolol HCl is selected as a drug candidate for the formulation of controlled release matrix tablets. The present work was aimed to formulate the controlled release matrix tablets of Propranolol for extending the drug release for a prolonged period of time. Controlled released matrix tablets of Propranolol hydrochloride was prepared by wet granulation process. All the tablets were evaluated for physical parameters such as weight uniformity, hardness, friability and drug content. The in vitro dissolution studies were carried out for all the matrix tablet formulations and the mechanism of drug release was elucidated.
Authors and Affiliations
M. Ramanaiah, B. Nagendra Babu, D. Jeevan Mani Babu
Keywords
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