Influence of Hyperhomocysteinemia on Development of Non-Alcoholic Fatty Liver Disease in Diabetes Mellitus
Journal Title: Міжнародний ендокринологічний журнал - Year 2013, Vol 1, Issue 49
Abstract
In 137 patients with diabetes mellitus, non-alcoholic fatty liver disease and with combination of these diseases there had been studied the pathogenetic mechanisms of hyperhomocysteinemia influence on formation of non-alcoholic fatty liver disease. The following disorders were revealed: the augmentation of homocysteine content; atherogenic types of dyslipidemia; disorders of bile-secreting liver function, of all types of metabolism; development of endothelial dysfunction; disorders of lipid peroxidation system and antioxidant activity in patients with diabetes mellitus, non-alcoholic fatty liver disease, that led to disorder of hepatocytes integrity, development of fatty hepatosis and increase of incidence of late complications of diabetes mellitus.
Authors and Affiliations
A. V. Vlasenko
Keywords
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