Influence of hypothyroidism in men on androgenic function
Journal Title: Міжнародний ендокринологічний журнал - Year 2018, Vol 14, Issue 8
Abstract
Background. The results of modern researches specify the role of thyroid hormones, metabolic imbalance, psychological stress involved in the maintenance of general and hormonal homoeostasis. At the same time, correlation between thyroid and sexual hormones in men with hypothyroidism remains controversial issue. Research purpose was to study the frequency of clinical and laboratory signs of androgenic deficiency, as well as the influence of insufficient level of thyroid hormones on the androgenic function in men with primary hypothyroidism. Materials and methods. Under a supervision, there were 55 men with primary hypothyroidism aged 36 to 60 years, and also 25 apparently healthy men. Results. Patients with hypothyroidism had a significant decrease in the concentration of sex hormone-binding globulin (SHBG), total testosterone, and also free and bioavailable testosterone compared to healthy men. In patients with hypothyroidism, the serum concentration of free thyroxine positively correlates with SHBG. Negative moderate correlations were detected between SHBG and free and bioavailable testosterone. Conclusions. For the middle-aged men with hypothyroidism, determination of androgen content is recommended to detect the syndrome of androgenic deficiency.
Authors and Affiliations
T. I. Krytskyi
Keywords
Related Articles
- EP ID EP460061
- DOI 10.22141/2224-0721.14.8.2018.154851
- Views 71
- Downloads 0
Prevalence of Arterial Hypertension in Urban Population of Ukraine Depending on the Degree and Type of Obesity
The objective of this study was subanalysis of the prevalence and detection of arterial hypertension (AH) among patients with overweight and obesity depending on the degree and type of obesity in a large population study...
Smoking Cessation in Patients with Cardiovascular Diseases
The article deals with the problem of Smoking, described the harmful effects of nicotine on the cardiovascular system, provides statistical data on the prevalence of Smoking in Ukraine. The article describes methodical r...
Management of Patients with Adrenal Incidentalomas
The problem of choosing the tactics of the management of patients with adrenal incidentalomas is topical without doubt, considering the widespread use of modern instrumental methods for topical diagnosis. Despite the vas...
Genetic basis of endocrine pathology
The purpose of the review was analysis of literature data relating to the molecular genetic basis and diagnosis of endocrine pathology. We searched for published and unpublished researches using Pubmed as the search engi...
Anticoagulation Therapy with Bemiparin in Combination Treatment of Patients with Diabetic Peripheral Neuropathy and Latent Ischemia of Lower Limb Tissues
It is known that diabetic peripheral neuropathy as well as microangiopathy increases risk of diabetic foot syndrome development even with preserved patency of main arteries of the lower limbs. In this paper we examined t...