Influence of Mebivid on the Structural and Functional State of Bone Tissue in Experimental Nutritional Osteoporosis
Journal Title: Біль. Суглоби. Хребет - Year 2015, Vol 4, Issue 20
Abstract
To determine the impact of domestic combined preparation mebivid containing vitamin D3 and bisphosphonate on the normalization of the structural and functional state of epiphyseal cartilage and bone tissue, we have conducted an experimental study on 30 Wistar rats weighing 90 ± 5 g. We used nutritional model of osteoporosis. Histomorphologic and osteometric studies were carried out, bone ash content was determined. The study found that mebivid effectively influences the normalization of disorders of the structural and functional state of epiphyseal cartilage and bone tissue in the nutritional osteoporosis in rats. Experimental studies demonstrate the feasibility of using a combined drug mebivid in the treatment of orthopedic diseases associated with impaired longitudinal growth, increase in thickness and structural and functional state of bone tissue.
Authors and Affiliations
A. T. Brusko, L. I. Apukhovska, A. V. Kalashnikov, O. V. Kalashnikov, V. D. Malyk
Keywords
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