INFLUENCE OF MERCAZOLILUM AND MELATONIN ON THE REGULATION OF FIBRIN AND PROTEOLYTIC PROCESSES IN BLOOD PLASMA OF WHITE RATS
Journal Title: Science Review - Year 2018, Vol 3, Issue 2
Abstract
It is known that the highest concentrations of melatonin in the body are registered in organs of the gastrointestinal tract, heart and blood plasma. In addition, there is a rhythm of sensitivity to melatonin organs and systems that can determine the peculiarities of the hormone's effect on fibrinolysis. In our opinion, this effect may be due to the combined effect of the hormone of the epiphysis - melatonin, and the inhibition of thyroid function in the administration of Mercazolil. The results of the combined effect of Mercazolilum and Melatonin on the fibrin and proteolytic processes in the blood plasma of white rats are presented in the work. According to the results of our study in blood plasma, the intensity of enzymatic lysis of fibrin under the influence of indolamine increases, it can be explained by a different phase of chronotropy to melatonin. In conducted experimental studies on non-linear males of hypothyroid white rats, it was found that melatonin causes an increase in the intensity of enzymatic and non-enzymatic fibrinolysis and a decrease in the parameters of proteolytic activity of plasma.
Authors and Affiliations
V. V. Antsupova, S. I. Аnokhina, I. A. Ushko, V. G. Ostapchuk, N. V. Shvets
Keywords
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