Influence of Metronidazole on Oral Busulfan Test Dose
Journal Title: International Journal of Transplantation Research and Medicine - Year 2016, Vol 2, Issue 1
Abstract
Abstract: Individualization of busulfan (BU) dosing during pre-transplant conditioning for hematopoietic stem cell transplantation (HSCT) has been performed worldwide for more than a decade. The pharmacokinetic parameters of BU show high variability and studies report that high plasma concentrations (> 900 ng/mL) are associated with sinusoidal obstructive syndrome (SOS), whereas low plasma concentrations (< 600 ng/mL) are associated with graft rejection and/or disease recurrence.
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- EP ID EP343415
- DOI 10.23937/2572-4045.1510019
- Views 140
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