Influence of suppositories with content of fe nanoparticles on immunolodical system of organism of cows
Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2017, Vol 30, Issue
Abstract
Introduction. The rapid development of nanotechnology has led to their widespread use in various fields of science and technology. The use of nanoparticles caused, mainly, their physical and chemical properties represented by objects of the 1-100 nm size.Applying of complex metal nanoparticles compounds in medical practice is an alternative of antibiotics use in the farm animal’s treatment that is preventing the risk of antibiotic resistance in consumers of livestock products. Thus, the development of means where metal nanoparticles have a wide spectrum of action, high biological activity and low toxicity is important.The goal of the work. Construct suppositories containing copper nanoparticles and examine their impact of immunological system and postnatal period.Materials and methods. Experiment was conducted in LLC “Agroprodservice invest” of Ternopil oblast in dairy cattle of Ukrainian black and white breed. Biochemical studies conducted in the laboratory of veterinary obstetrics and gynecology of Ternopil Research Station of the Institute of Veterinary Medicine the of NAAS.Research of cow’s blood for the contest of immunoproteins A, M, G was conducted at the beginning and the end of postnatal period, after suppositories containing copper nanoparticles application.Results of research and discussion. After intrauterine application of suppositories with Fe nanoparticles in cow’s organism content of secretory immunoglobulin A increased in 3.9 times (р≤0,01), the content of immunoglobulin M increased increased in times 2.8 (p≤0,001) and the content of immunoglobulin G reduced in 4 times (p≤0,001).Our data give reason to suggest that in the cow’s organism the immunoglobulin A is actively produced by endometrium and provided the local immunity and prevent the development of genital infections in the postnatal period. Increase of immunoglobulin M after suppositories application indicate the activation of the complementary system of the cow’s organism and reduction of immunoglobulin G activation process indicate the absorption and digestion of antigens by phagocytes.After application of suppositories containing nanoparticles of Fe in cows the duration of the service period reduced by 14 days (p≤0,05) and insemination index decreased by 0.2 units compared to control group.Conclusions and prospects for further research. After intrauterine application of suppositories with Fe nanoparticles in the body of cows increased the content of immunoglobulin A in 3.9 times (p≤0,01), the content of immunoglobulin M 2.8 in times (p≤0,001) and reduced the content of immunoglobulin G 4 in times (p≤0,001).The use of suppositories with Fe nanoparticles prevent the development of a uterus involution and reduce the length of service period on 14 days (p≤0,05) and insemination indexunits.
Authors and Affiliations
I. Kobylukh, Yaroslav Stravskyy, L. Reznіchenko
Keywords
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- EP ID EP269671
- DOI 10.31073/vet_biotech30-13
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