INFLUENCE OF SYNTHETIC ETHROGENES IN FOOD PRODUCTS ON THE DETOXICATION SYSTEM OF ANIMAL ANIMALS OF DIFFERENT AGE
Journal Title: Наукові доповіді НУБіП України - Year 2018, Vol 2, Issue 2
Abstract
The effect of synthetic estrogens on the state of peroxide oxidation of lipids and total antioxidant activity in animals of different ages in in vivo and in vitro have been investigated. In the analysis of data obtained during the effect of alimentary exogenous estrogen in kidneys and liver increase of peroxidation of lipids, the degree of which exceeded the activation of the antioxidant system was determined. In females in puberty, the reaction of the prooxidant system exceeded the force of response in organs of sexually mature animals. It can be assumed that such shifts can further become a trigger for reducing the potential of compensatory mechanisms in particular adaptation which is an important pathogenic link of the disease of the organs of excretion and detoxification. Exposure of synthetic estrogens in vitro led to the reduction of POL in female tissues in the puberty period and in the sexually mature rats by activating the antioxidant system by increasing thiol groups and agonist effects on enzymes. Violation of the sensitive balance between free radicals and antioxidants can lead to cell damage, which may indicate the existence of specific age-related physiological conditions determining high sensitivity to exogenous estrogen-like compounds.
Authors and Affiliations
T. Y. Lykholat, O. M. Marenkov, K. V. Yashchenko, E. S. Shaldyna, O. A. Lykholat
Keywords
Related Articles
- EP ID EP294934
- DOI -
- Views 85
- Downloads 0
EFFECT OF MICRONUTRIENT SUPPLEMENTATION IN THE DIET OF FEMALE CARPS IN PRESPAWING PERIOD ON LIPID IN THE CAVIAR AND LARVAE OBTAINED FROM THEM
The study was conducted on 2 groups of carp 5 years age, which by the principle of analogues were divided into control and experimental groups of 10 individuals in each. Fish kept in special trays under conditions of con...
STRUCTION OF MATHEMATICAL MODEL IN CHANGES OF NUMBERS RED BLOOD CELLS IN PRESERVED BLOOD OF ANIMALS BY SAVING
In the work we can see a problem of building mathematical model in changes of numbers red blood cells in preserved blood of animals by saving, which is based on the results of experimental work. Red blood cell are playin...
IDENTIFICATION OF HYBRID CORN CARYOPSES BY PIGMENTATION OF ALEURONE LAYER
Contamination of the main crop batch with varieties and hybrids of other agricultural crops affects the final product quality. Particularly, it is necessary to control the genetic purity of hybrid corn seeds, since its c...
DESIGN OF NON-LINEAR MATHEMATICAL MODEL FOR EVALUATION OF APPLICATION EFFICIENCY TO LANDSCAPE ZONES OF ZAKARPATTIA
To evaluate the application efficiency of agricultural lands through the perspective of soil fertility the degree of land use efficiency and the concept of agricultural sustainability as the practical implementation of s...
CHANGES OF THE NON-SPECIFIC LAMB OF IMMUNITY IN THE ORGANISM OF THE DUCKS OF THE PEKIN BREED IN THE POSTNATAL PERIOD OF ONTOGENESIS
The article presents the results of the study describing the adaptation of the humoral and cellular level of nonspecific resistance and aspects of the immunological adaptation of the duck organism during the critical per...