Influence of the zearalenone on the activity of chosen liver enzymes in a rat.
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2009, Vol 16, Issue 1
Abstract
Zearalenone is a mycotoxin compound produced mainly by Fusarium species of fungi which is present in cereals cultivated all over the world. The aim of the research was to examine the toxic influence of different doses of zearalenone on liver cells through estimating mycotoxin influence on markers evaluation of biochemical liver damage. The research was carried out on male Wistar rats. The rats were divided into 9 groups of 10 animals each. Group A was orally given 8% ethyl alcohol. Group B, C, D, E was orally given once a day for 10 days a zearalenone alcohol solution properly in dose of 50, 100, 200, 500 microg/kg b.w. Single doses of zearalenone was given to the animals from groups X, Y, Z and W. Control group W - 8% ethyl alcohol, group X dose 1 mg/kg b.w., group Y dose 2 mg/kg b.w., group Z dose 3 mg/kg b.w. For the research, blood was taken from hearts. The blood was centrifuged and the plasma analyzed using spectrophotometric methods: aspartate and alanine aminotransferase, alkaline phosphatase and complete bilirubin. The results of the experiment show that liver cells are exposed to zearalenone activity increased liver aminotransferases (ALT and AST) in blood plasma. Rise of liver aminotransferase level (ALT and AST) in animal's blood plasma after giving zearalenone may confirm the hepatotoxic influence of this mycotoxin. Short-lasting zearalenone influence does not cause changes in the liver aminotransferases.
Authors and Affiliations
Adam Stadnik, Andrzej Borzecki
Keywords
Related Articles
- EP ID EP58623
- DOI -
- Views 196
- Downloads 0
Prevention of female reproductive system cancer among rural and urban Polish pregnant women.
Based on data obtained from the system MoZMaD - PL (Polish Mother and Child Health Monitoring System; an equivalent of the American system PRAMS (Pregnancy Risk Assessment Monitoring System). In the developed countries p...
Treatment of lower limb trophic ulcers using hyperbaric oxygenation
[b]Introduction.[/b] Lower limb venous ulcers affect approximately 1–1.3% of the population and constitute the most dangerous and distressing complication related to chronic venous insufficiency. Although the issue of tr...
Nutritional behaviours of pregnant women in rural and urban environments
Introduction. Monitoring of the environmental differences in the mode of nutrition is especially important in pregnant women, for whom normal body weight gain is especially important for both the course of pregnancy and...
Usage of leisure time by disabled males and females from the Lublin Region
Introduction. Free time in the life of both the disabled and those who are able bodied is the time of leisure, recovery and entertainment. The disabled utilize more energy and strength for everyday functioning compared t...
Increasing role of arthropod bites in tularaemia transmission in Poland – case reports and diagnostic methods
The study describes four cases of tularaemia – one developed after contact with rabbits and three developed after an arthropod bite. Due to non-specific clinical symptoms, accurate diagnosis of tularaemia may be difficul...