Influence of violations of non-specific and systemic cell response to the efficiency of the chemotherapy of pulmonary multidrug-resistant tuberculosis

Abstract

Objective — is to establish violations in the immune system that aggravate the course and reduce the effectiveness of the treatment of patients with multidrug­-resistant pulmonary tuberculosis. Materials and methods. A comparative analysis of violations of the non­specific and systemic cellular immune response at the link was performed in 44 patients with a newly diagnosed destructive multidrug-­resistant pulmonary tuberculosis (NDD MDR-TB) with effective, not very effective and ineffective antimycobacterial therapy (AMBT). Results and discussion. In patients with NDD MDR-TB inefficient and not very effective therapy, compared to patients treated efficiently, available pronounced humoral type immune response: increased by an average of 20—25 % content of ІgА (р < 0.05), ІgМ (р < 0.05), ІgЕ (р < 0.05) and the level of circulating immune complexes (p < 0.05); reduced content of cationic lysosomal proteins (CLP) of granulocytic leukocytes (р < 0.001), suppressed proliferative activity of T-lymphocytes on nonspecific (FSH, p < 0.05) and specific (PPD-L, p < 0.05) mytogens. In patients with treatment failure 2.0 times more frequently observed inhibition of 30 — 50.0 % or more proliferative activity of T-lymphocytes, the proportion of individuals with signs of tuberculin anergy of specific T-lymphocytes increased in 1.7 times and the proportion of patients with a decreased content of CLP granulocytes increased in 1.5 times. Significant disorders in the immune system were detected in 70 % of patients with ineffective and 29.4 % of patients with effective treatment. Conclusions. Progression specific process and reduce of the efficiency AMBT MDR-TB contribute: the presence of T-cell immunosuppression expressed by a decrease of more than 30.0 % of the T-lymphocyte pool and inhibition of their proliferative activity; tuberculin tolerance of specific T-lymphocytes, phago­cytic insufficiency is caused by a decrease of 30.0—50.0 % of the CLP content of granulocytic leukocytes.

Authors and Affiliations

І. L. Platonova, M. І. Sahelashvili, N. E. Lapovets, О. А. Tkach, G. V. Schurko

Keywords

Related Articles

Possibilities of surgical treatment of pulmonary aspergillosis

Objective — to present our own experience of surgical treatment of pulmonary aspergillosis. Materials and methods. During last ten years, 18 patients with pulmonary aspergillosis were observed. In 14 (77.8 %) cases aspe...

Features of relationships of patients and the doctor in the clinic of tuberculosis

With the scientific, technological and industrial potential of humanity on the rise, as well as advancement in the ability to improve the environment and significantly change its conditions of existence, the moral questi...

Determinants of the loss to follow-up of the patients with tuberculosis and the role of the social support

Tuberculosis represents a major global health problem. The major social determinants of tuberculosis and poor disease outcome are social and economic inequalities, high level of migration, rapid urbanization. Objective...

Chronic obstructive pulmonary disease: realities top respiratory medicine problems with the present positions

Objective — evaluation of the situation with the common diseases of the broncho-pulmonary system and analysis of the prospects for the establishment of COPD control from the point of view of the present. Used access to v...

Significance of ultrasonoscopy in early detection of syndrome of pleural effusion

Objective — to study the importance of ultrasonoscopy for the timely detection of pleural effusion syndrome, taking into account the nature of the changes, the level of radiation exposure and the develop­ment and prevale...

Download PDF file
  • EP ID EP674691
  • DOI 10.30978/TB2019-3-14
  • Views 98
  • Downloads 0

How To Cite

І. L. Platonova, M. І. Sahelashvili, N. E. Lapovets, О. А. Tkach, G. V. Schurko (2019). Influence of violations of non-specific and systemic cell response to the efficiency of the chemotherapy of pulmonary multidrug-resistant tuberculosis. Туберкульоз, легеневі хвороби, ВІЛ-інфекція, 0(3), 14-19. https://europub.co.uk./articles/-A-674691