Influence of β-cyclodextrin on the Properties of Norfloxacin Form A
Journal Title: AAPS PharmSciTech - Year 2015, Vol 16, Issue 3
Abstract
Cyclodextrins are able to form host–guest complexes with hydrophobic molecules to result in the formation of inclusion complexes. The complex formation between norfloxacin form A and β-cyclodextrin was studied by exploring its structure affinity relationship in an aqueous solution and in the solid state. Kneading, freeze-drying, and physical mixture methods were employed to prepare solid complexes of norfloxacin and β-cyclodextrin. The solubility of norfloxacin significantly increased upon complexation with β-cyclodextrin as demonstrated by a solubility isotherm of the AL type along with the results of an intrinsic dissolution study. The complexes were also characterized in the solid stated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffractometry, scanning electron microscopy (SEM), and solid-state nuclear magnetic resonance (ssNMR) spectrometry. The thermal analysis showed that the thermal stability of the drug is enhanced in the presence of β-cyclodextrin. Finally, the microbiological studies showed that the complexes have better potency when compared with pure drug.
Authors and Affiliations
Lucas Chierentin, Claudia Garnero, Ana Karina Chattah, Poonam Delvadia, Thomas Karnes, Marcela Raquel Longhi, Hérida Regina Nunes Salgado
Keywords
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- EP ID EP682256
- DOI 10.1208/s12249-014-0259-8
- Views 88
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