INHIBITION OF AMPA RECEPTORS AND ACTIVATION OF THE GLYCINE SITE OR POLYAMINE SITE OF NMDA RECEPTORS AT THE SUPRASPINAL LEVEL INDUCES ANTINOCICEPTION
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 3
Abstract
At the supraspinal level, the role of AMPA receptors in the mechanism of pain remains to be fully clarified, even though they are found in large numbers throughout many brain regions. The results of this study revealed that intracerebroventricular administration of YM872, an AMPA receptor antagonist, exerted a dose-dependent antinociceptive effect on acute and tonic pain such as that induced by the tail flick or formalin tests without sedation or signs of abnormal behavior in rats. Moreover, the antinociceptive effect induced by intracerebroventricular administration of YM872 together with D-serine, an endogenous co-agonist for the glycine site of the NMDA receptor, or spermidine, an endogenous allosteric modulator for their polyamine site, was larger than that by application of YM872, D-serine, or spermidine alone in the formalin test. These results suggest that inhibition of AMPA receptors and/or activation of NR2B-containing NMDA receptors at the supraspinal level induces an antinociceptive effect on both acute and tonic pain.
Authors and Affiliations
Dr. Masanobu Yoshikawa
Keywords
Related Articles
- EP ID EP628157
- DOI -
- Views 192
- Downloads 0
EPISTAXIS IN CHILDREN: COMPARITIVE ANALYSIS OF TOPICAL ANTISEPTIC AND CAUTERY VERSUS TOPICAL ANTISEPTIC ALONE
Objective: To evaluate and compare different modalities in management of simple recurrent epistaxis in children. Patients and methods: A total of 148 children (age 5-14 years) presented to ENT clinic with recurrent epist...
SOLID DISPERSION INDUCED CO-CRYSTALLIZATION FOR ENHANCED DISSOLUTION RATE OF NEBIVOLOL HYDROCHLORIDE: DEVELOPMENT OF RAPIDLY DISINTEGRATING TABLETS
Nebivolol hydrochloride is an antihypertensive agent which is classified as class II drug. Its oral bioavailability is variable due to its poor dissolution and pre-systemic metabolism. The aim of this work was to enhance...
MARFAN SYNDROME WITH PLEURAL EFFUSION
Introduction: Marfan syndrome is rare autosomal disorder of the connective tissue affect both male and female equally, manifested with skeletal, ligamentous, orooculofacial, ophthalmic, pulmonary, neurological and most f...
EFFICACY OF LEAVES POWDER OF BAMBUSA ARUNDINACEA ON ANTITHROMBOTIC ACTIVITY
This study was a comparative in vivo study, conducted in Wistar albino rats at Unit of Siddha Medicine, Trincomalee Campus, Eastern University of Sri Lanka. Thrombosis is the formation of a blood clot inside a blood vess...
THE ROLE OF REHABILITATION AS AN ADJUNCT TO MEDICATION IN ACUTE CORONARY SYNDROMES
Purpose: The aim of this paper is to assess the impact of cardiac rehabilitation through a systematic review comparing cardiac rehabilitation to pharmacological treatment assessing the benefits and risks associated with...