Initial Outcomes and Assessment of the Transperineal Multiparametric-Magnetic Resonance Imaging/Ultrasonography Fusion Biopsy Method in Diagnosing Clinically-significant Prostate Cancer
Journal Title: Üroonkoloji Bülteni - Year 2017, Vol 16, Issue 2
Abstract
Objective: In this study, it was aimed to investigate the success of transperineal multiparametric magnetic resonance imaging (mp-MRI)/transrectal ultrasonography (USG) fusion prostate biopsy method in prostate cancer diagnosis and detection of clinically significant cancer. Materials and Methods: All patients signed written informed consent then patients with an indication for prostate cancer, therefore biopsy was planned for the last year underwent 3 Tesla mp-MRI retrospectively. All the lesions of patients with Prostate Imaging, Reporting and Data System (PIRADS) 3, 4 and 5 lesions were marked using MIM™ Symphony software by a single radiologist. All patients underwent transperineal MRI/USG fusion biopsy under general anesthesia. In the prostate MRI evaluation of the targeted lesions with a PIRADS score of 3-4-5 were sampled with 2 to 5 cores followed by random biopsies of both of the prostate lobes. Results: Prostate adenocarcinoma was diagnosed in 20 of 59 patients (33.8%) having fusion biopsy. No difference was observed in prostate-specific antigen levels of patients whose biopsy results were benign and malignant. In 63% of patients, only PIRADS 3 lesions were found, whereas PIRADS 4 and/or 5 lesions were reported in 22 (37%) patients. The fusion biopsy of PIRADS 3 lesions revealed cancer in 7 patients (19%), of which 6 had clinically-insignificant prostate cancer criteria. Adenocarcinoma was diagnosed in 59% who had PIRADS 4 and/or 5 lesions. All these tumors had clinically-significant cancer characteristics. Lesion-targeted fusion biopsies missed 1 clinically-insignificant adenocarcinoma (1/7; 14.3%), while it did not miss any of the clinically-significant cancers. No infection was seen in post-operative period. Acute urinary retention was developed in 4 patients (6%). Conclusion: The findings in the initial period give rise to the thought that lesion targeted prostate biopsy method may have a crucial role in especially determining clinically-significant cancer. Prospective randomized studies with larger numbers of patients and especially comparison of different fusion biopsy platforms, are needed in order to assess the diagnostic success of MRI/USG fusion biopsy fully.
Authors and Affiliations
Mahir B. Özgen, Bora Özveren, Sertaç Uzel, Uğur Altuğ, Levent Türkeri
Keywords
Related Articles
- EP ID EP226695
- DOI 10.4274/uob.805
- Views 127
- Downloads 0
Evaluation of Role of Inflammatory Markers for the Prediction of Recurrence on Pathologic T1a Clear Cell Renal Cell Cancer Patients
Objective: To evaluate the role of neutrophil to lymphocyte ratio (NLR), high sensitive C-reactive protein (hs-CRP) and procalcitonin levels in the prediction of tumor recurrence in stage T1aN0M0 clear cell renal cell ca...
Importance of the Re-Transurethral Resection in Bladder Cancer Treatment
Objective: In this study, we aimed to investigate the importance of repeat-transurethral resection (re-TUR) in bladder cancer treatment. Materials and Methods: A total of 90 with the diagnosis of grade pTa and all pT1 bl...
The Optimum Dosage of Prilocaine in Periprostatic Nerve Block During Transrectal Ultrasound Guided Prostate Biopsy: A New Approach in Dose Calculation
Objective: We aimed to calculate the optimum dose of prilocaine per one mL prostate volume in periprostatic nerve block (PPNB) during transrectal ultrasound (TRUS) guided prostate biopsy (PBx). Materials and Methods: We...
Evaluation of General Characteristics of Renal Cell Carcinoma Patients: A Single Center Experience
Objective: Renal cancer (RC) accounts for 3.2% of all newly diagnosed cancers and approximately 90% of RC cases are renal cell carcinoma (RCC). Smoking and hypertension are the most important risk factors. The aim of our...
A Rare Case: Contralateral Testicular Seminoma Accompanied by Right Undescended Testicle and Right Inguinal Hernia with Ipsilateral Renal Agenesis and Seminal Vesicle Agenesis
Due to the close relationship between the male reproductive system and the urinary system, both embryological and congenital anatomic anomalies of these systems are often seen together. Seminal vesicle agenesis is a rela...