Insight into the role of microRNAs in reactive oxygen species activity
Journal Title: RATS - Year 2023, Vol 1, Issue 2
Abstract
MicroRNAs (miRNAs) are non-coding RNAs and have a pivotal role in a range of mechanisms related to physiologi-cal and pathological conditions in humans. Reactive oxygen species (ROS) are unstable molecules derived from oxygen ions and initially produced during mitochondrial oxidative phosphorylation. These levels are tightly related to several diseases, such as cancer pathogenesis, neurodegenerative, cardiovascular, inflammatory, and apoptosis-related disea-ses. In recent years, ROS-related specific miRNA expression levels have gained attraction in the fields of pathology, mo-lecular biology, physiology, pharmacology, and tissue engineering. Interestingly, both increases and decreases in miRNA expression have dual effects on ROS production. Variable changes occur during a ROS-related disease in the expression levels of miRNAs. The main point is the clarification of whether the increase or decrease of the related miRNAs has a suppressive, scavenger, or therapeutic effect on ROS. There is still a lack of substantial evidence about the relationship between ROS. Here we summarized the relationship between ROS production and miRNAs from a narrative perspective.
Authors and Affiliations
Cemre Aydeğer, Hüseyin Avni Eroğlu
Keywords
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- EP ID EP726892
- DOI 10.5281/zenodo.10444606
- Views 58
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