Insulinemic Status and Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 12
Abstract
Introduction: In this article, non -alcoholic fatty liver disease (NAFLD) is discussed in detail. The epidemiology of NAFLD nonalcoholic steatohepatitis and the relationship of NAPLD with type 2 diabetes mellitus insulinemic resistance are broadly discussed. NAFLD incorporates histologically and clinically different non-alcoholic entities fatty liver (NAFL, steatosis hepatis) and steatohepatitis (NASH characterized by hepatocyte ballooning and lobular inflammation + fibrosis) might progress to cirrhosis and rarely to hepatocellular cancer. Type 2 diabetes mellitus (T2DM), insulin resistance (IR), obesity and NAFLD are particularly closely related. Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) commonly exist together. Age is major determinant of NAFLD. As Body mass index and waist-to-hip ratio were not independently associated with nonalcoholic fatty liver diseases in our study, suggesting that obesity might also be effects of insulin resistance. Insulin resistance leads to foot accumulation in hepatocytes by lipolysis and hyperinsulinemia. Objective: The objective of the study was to find out the association of NAFLD with insulinemic status in type 2 DM subjects. Results: The present data leads to the suggestion that there is a strong association between insulin resistance and NAFLD. However, the question of whether hyperinsulinemia or insulin resistance is the primary disorder of NAFLD remains unangered. Further studies are needed to elucidate interrelationship between NAFLD, metabolic syndrome and insulin resistance.
Authors and Affiliations
Dr Azmeri Alam
Keywords
Related Articles
- EP ID EP502002
- DOI -
- Views 69
- Downloads 0
Colonic Adenocarcinoma Presenting as Hemophagocytic Syndrome: A Case Report
Hemophagocytic syndrome is a rare and potentially fatal disorder characterised by pathological immune activation associated with primary familial disorder, genetic mutation or occurring as a sporadic condition. The later...
Clinical Profile and Visual Morbidity in Firecracker Eye Injuries
Purpose: To study the clinical profile and visual morbidity in firecracker eye injuries. Material and Methods: Hospital based prospective study of 32 patients came due to fire cracker injuries during 3 days of Deepawali...
Association of Aortic Knob Calcification with Intracranial Stenosis in Ischemic Stroke Patients in Tertiary Care Centre
Background: In the arterial bed, Deposition of calcium may indicate the extent of atherosclerotic lesions and aortic knob calcification (AC) is associated with increased risks of cardiovascular and cerebrovascular events...
Management of 3 yrs old child with congenital tracheomalacia posted for inguinal hernia repair
Tracheomalacia is characterized by the flaccidity of the tracheal cartilages which helps in keeping the airway (trachea) open, resulting in the airway collapse in the conditions of increased airflow. It can be congenital...
Study of Impact of Interdisciplinary Seminar as an Integrated Teaching - Learning Innovation in M.B.B.S Students
Introduction- Integration of teaching method is very important in overcoming the barriers of learning. In order to improve learning and understanding of students, innovative educational approaches have been introduced, s...