Integrin αvβ6 as a Prognostic Indicator in Breast Cancer: a comparative studyof China and India.
Journal Title: PARIPEX-Indian Journal of Research - Year 2017, Vol 6, Issue 3
Abstract
Background and Objective: Integrin αvβ6 serves a vital role in the progressive development of cancer. The distribution of αvβ6 integrin are seen in proliferating epithelia especially around the lungs and mammary cells. In this study our aim was to determine the expression of Integrin αvβ6 and compare between China and India. Methodology: The level of expression for integrin αvβ6 was evaluated in breast cancer tissues and paraneoplastic tissues of 80 cases from China and 80 cases from India via immunohistochemical stain. Results: The level of expression for integrin αvβ6 was notably related with histological grade(China group P=0.0471, India group P=0.0051) and axillary lymph node involvement(China group P=0.0471, India group P=0.0003). The survival analysis by Kaplan- Meier indicated the median follow-up time of two groups was lower with positive integrin αvβ6 (China group P=0.016, India group P=0.004, the log-rank test). Conclusion: Integrin αvβ6 is the prognostic indicator for invasiveness and metastatic development of breast cancer in both China and India and could be an important factor for treatment in the near future.
Authors and Affiliations
Dr Siddhartha Biswas, Dr Ze Qun LI, Dr ABM Kaiser, Dr Jun Niu
Keywords
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