INTEGRITY OF VISUAL PATHWAY IN DIABETES MELLITUS – AN ELECTROPHYSIOLOGY BASED ASSESSMENT
Journal Title: International Journal of Basic and Applied Physiology - Year 2018, Vol 7, Issue 1
Abstract
Background: Diabetic retinopathy being a major cause of blindness worldwide, early identification of the functional changes in the retina well before the onset of clinically evident retinopathy, helps to prevent adverse complications in future. Visual evoked potentials (VEP) may serve as a simple, non- invasive effective screening tool in assessing the integrity of visual pathway in diabetic patients and thereby may help in early intervention. Hence the present study aimed to study the integrity of visual pathway in diabetic patients using measurement of visual evoked potentials. Methods: About 180 individuals in the age group of 45-60 years were recruited from the patients attending the Ophthalmology and Medicine OPD of our institution. Visual evoked potentials were measured in the diabetic patients with and without retinopathy and the results were compared with the nondiabetics. Results: Diabetic patients without clinically evident retinopathy had significantly lesser amplitude and prolonged latency of VEP parameters compared to the nondiabetics. A significant positive correlation was found between the duration of the disease and the VEP parameters. Interpretation and Conclusion: Functional alteration as evidenced by prolonged P100 latency may precede well before the onset of vascular changes in the retina, as evidenced by retinopathy. VEP measurement may serve as a simple, non-invasive prognostic marker of the disease, thereby may help to improve patient compliance and prevent overt complications in future. Further duration of the diabetes may significantly contribute to retinal dysfunction.
Authors and Affiliations
k soundariya, shanmugappriya S
Keywords
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