Interaction model between quercetin (3,5,7,3p,4p-pentahidroxiflavone) and human shock thermic factor (HFS)
Journal Title: Revista Cuarzo - Year 2016, Vol 22, Issue 2
Abstract
INTRODUCTION. The expression of the HSP stress inducted are regulated by the Shock Thermic Factor (HSF), that exists in an in-active form as a monomer and when it becomes a trimer can make a bind to DNA activating the HSP transcription. OBJECTIVE. Design a computational model that helps elucidate possible interactions between quercetin fl avonoid and proteins such as HSF-1. METHODOLOGY. To observe how the quercetin possibly affects the timerization of HFS, we make an homology mo-del of the human shock factor (HFS-1), obtaining a high structural homology model with the same protein in Kluyve-romyces lactis, this model was used to make docking with the fl avonoid quercetin ( 3,5,7,3p,4p-pentahidroxifl avone). RESULTS AND CONCLUSION. The doking result shows that the quercetin docks to a loop (wing), that is important in the protein-protein interaction, possibly affecting they’re trimerization
Authors and Affiliations
Clavijo B. , D. , Yosa R. , J. , Acevedo S. , O. , Cifuentes, C. , & Estévez Bretón, C.
Keywords
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- EP ID EP694604
- DOI https://doi.org/10.26752/cuarzo.v22.n2.164
- Views 144
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