Interaction of aldose reductase and superoxide dismutase activity in liver; influence of vasopressin hormone and its modulators
Journal Title: International Journal of Biomedical Research - Year 2015, Vol 6, Issue 10
Abstract
The Liver is an important organ of the body for carbohydrate metabolism which include ureogenesis, glycogenolysis, gluconeogenesis. The pituitary hormone vasopressin mediates its actions on the carbohydrate metabolism through the V1 receptors expressed in the Liver. The vasopressin V1 receptors are coupled to the phospholipase C mediated signalling pathway. In this article, the focus is on the effects of vasopressin on superoxide dismutase (SOD) and Aldose reductase (ALD) enzyme activity in the Liver. It also stresses on the role of calcineurin phosphatase which may be involved in ROS generation. The possible homeostatic balance between superoxide generation and polyol pathway during liver injury and the role of vasopressin hormone is also discussed
Authors and Affiliations
Manoj G Tyagi, William T Raja, Jayanta K Dey, Arumugasamy K.
Keywords
Related Articles
- EP ID EP419988
- DOI 10.7439/ijbr.v6i10.2600
- Views 115
- Downloads 0
Prediction of peak expiratory flow rate from armspan in healthy children aged 8 to 12 years
Peak expiratory flow rate (PEFR) was measured in 400 normal healthy school going children in the age group of 8 to 12 years of Lucknow city. It was observed that there was a gradual, parallel progressive increase in the...
Efficacy of parenteral iron sucrose in treatment of pregnancy associated iron deficiency anemia with special reference to body iron stores
Worldwide Iron deficiency anemia (IDA) affects 25% population and in India it affects 80% of pregnant. Prospective interventional study was conducted to know the efficacy of intravenous (IV) iron sucrose in the managemen...
Epidemiological study of chemical and thermal ocular injuries at a rural hospital in eastern Maharashtra
Chemical and thermal injuries to the eye may be rare incidence but are not uncommon and pose one of the challenging areas of practice for ophthalmologists irrespective of area of practice. The present study was undertake...
Trans-Anal Suture Rectopexy For Haemorrhoids
Background: Transanal suture Rectopexy (Chivates procedure)1 is a new invention by an Indian surgeon for managing all grades of haemorrhoids. It is based on the principles of plication of vessels in the rectum above dent...
Adolescent Pregnancy: An Assessment of a Rural Community in Plateau State, North Central Nigeria
Background: The incidence of adolescent pregnancy worldwide is on the increase and constitutes a major public health challenge.About 16 million women 15-19 years of age give birth each year and this account for 11% of al...