INTERCONNECTION BETWEEN THE KALLIKREIN-KININ SYSTEM AND ENDOGENOUS INTOXICATION OF RATS OF DIFFERENT AGE IN THE CONDITIONS OF THE EARLY AND LATE POLYTRAUMA
Journal Title: Наукові доповіді НУБіП України - Year 2018, Vol 2, Issue 2
Abstract
The interrelation between the kallikrein - kinin system (KKS) and endogenous intoxication (EI) in the early and late terms after the polytrauma modeling was examined. The research was conducted with 156 non- linear white rats at the age of 3, 6 and 24 months by polytrauma modeling. The material for biochemical research was taken at 1, 3, 24 hour and 14 day after injury. Activation of KKS confirms the presence of inflammatory process in animals with polytrauma. After polytrauma modeling of all examined age groups of animals, the increase of specific proteolysis by the Kallikrein (KK) can indicate the activation of adaptive protective reserves. With age, there is a slight exhaustion of nocifensor. The growth of the medium-weight molecules content of the animal organism after the polytrauma modeling indicates an increase in catabolic processes. Increasing the content of MWM254 may indicate the hepatocyte membranes failure, and MWM280 - an inhibition of detoxification function of the liver. Activation of the examined parameters confirms the presence of inflammatory process in animals with polytrauma, and there is a tendency to its greater increase in young animals. Data were obtained in favor of stable activation of total proteolysis in mature and elderly animals.
Authors and Affiliations
S. R. Pidruchna, H. M. Stepanova
Keywords
Related Articles
- EP ID EP294839
- DOI -
- Views 67
- Downloads 0
PHOTOSYNTHETIC POTENTIAL OF BURNS IN THE SURGERY OF THE CURRENT BREEDING FROM DEPENDENCE OF ITS HOST
The inoculation of crops of bioenergetic crops even within one soil-climatic zone has its own specifics. These features are primarily related to the conditions prevailing in crops of different crops, the beginning and du...
THE TROPHIC COMMUNICATION OF THE COTTON BOLLWORM IN THE MODERN GROWING TECHNOLOGY OF SUNFLOWER AND CORN IN THE FOREST-STEPPE OF UKRAINE
The features of reproduction of cotton shoots of sunflower seeds and corn under modern agricultural systems in the forest-steppe of Ukraine are highlighted. The analysis of efficiency of application of modern monitoring...
EFFICIENCY OF MICROBIAL PREPARATIONS IN TECHNOLOGY OF TOMATO GROWING
Microbial preparations and bioorganic fertilizers based on them provide improvement of mineral plants nutrition, stabilization and reproduction of soil fertility, promote increase of yield and obtain of high-quality prod...
SPATIAL HETEROGENEITY OF SOIL CONTAMINATION OF URBAN SYSTEMS WITH HEAVY METALS
The study determines the content of movable forms of heavy metals in the soils of Kherson on the territories (testing grounds) of different functional purposes: I testing ground – a selitable zone with multistory constru...
LEVEL OF HARMFUL GASES IN AIR OF THE SECTION FOR FARROW AT DIFFERENT SEASONS OF A YEAR AND CONDITIONS OF MICROCLIMATE
The aim of the research was to determine the level of ammonia and hydrogen sulfide in air of premise for sows under different conditions of creating microclimate depending on the season and temperature in sections and co...