Interferon Lambda 4 Gene (IFNL4) Linked to Hepatitis C virus clearance, treatment
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2017, Vol 67, Issue 0
Abstract
Background: AdesignatedIFNL4 gene, encoding the interferon-λ4 protein (IFNL4), which is moderately similar to IFNL3, is more strongly associated with HCV clearance in individuals of African ancestry, whereas it provides comparable information in Europeans and Asians. Aim of the work: The study was attempted for the identification of interferon Lambda 4 (IFNL4) gene expression in the liver biopsy and the recombinant IFNL4 protein in the serum of CHCV patients. Patients and methods: Eighty five patients with chronic hepatitis C virus infection (CHCV), whose age ranged between 19 and 57 years, were selected from the National Hepatology and Tropical Medicine Research Institute were included in this study, before chronic HCV therapy, during the preparation of patients, and ten healthy individuals were included to serve as controls. All the patients and controls were subjected to the following: history, clinical examination, abdominal ultrasonography and collection of blood samples for routine laboratory investigations, CBCs. Liver biopsy was done to all patients and controls. Patients revealed mild fibrosis (Metavir fibrosis from F1 to F3). Using freshly frozen liver biopsies to identify gene (IFNL4) by real time-PCR and the detection of its serum protein levels by ELISA. Results: Patientswith CHCVhave higher hepatic expression of IFNL4 before treatment and also recombinant IFNL4 protein expression was detectable in serum with high levels. Conclusion: An inducible human protein-coding gene IFNL4, which is related to, known IFNs have been identified in genotype 4 CHCV patients. Recommendations: Thetherapeutic inhibition of IFNL4 might represent a novel biological target for the treatment of HCV and HBV infection and possibly other diseases.
Authors and Affiliations
Saadia Farid1; Laila Rashed2; Samya Sweilam3
Keywords
Related Articles
- EP ID EP499472
- DOI -
- Views 119
- Downloads 0
Confidence, Perception, and Attitude towards Prescribing Antibiotics among Medical Students and Interns in Jeddah, Saudi Arabia
<span>Background: </span><span>According to the World Health Organization, antibiotics are the most frequently prescribed drugs worldwide. The development of antibiotics has successfully overcome the threat of infectious...
Autoimmune Hepatitis in Children: A Case Report
Background: Autoimmune hepatitis (AIH) is considered rare, and it is even rarer in the pediatric population. AIH in the pediatric population is categorized into type 1 and 2, which are differentiated by t...
Assessment of Follicular-Fluid Neurotrophin Levels as Predictor for Ovarian Reserve in Women Undergoing Assisted Reproductive Technology for Different Etiologies of Infertility
<strong>Background:</strong> brain-derived neurotrophic factor (BDNF) is a27-kDa polypeptide that belongs to the neurotrophin family binding with high-affinity protein kinase receptors (Trk) and the unselective p75NGFR r...
Variations of Corneal Hysteresis in Myopic Patients with Normal Pentacam Findings
<span>Background: </span><span>hysteresis refers to the energy lost during the stress/strain cycle which is the result of viscous damping in the corneal tissue, is an indicator of corneal biomechanical properties. Refrac...
Role of S-Iron and Ferritin to Predict the Response to Recent New Antiviral Treatment in Chronic Hepatitis C Patients
<strong><span lang="EN-US">Background: </span></strong><span lang="EN-US">Chronic hepatitis C (CHC) is an important liver disease, which may progress to cirrhosis or hepatocellular carcinoma. The current treatment regime...