Interleukin-6 serum concentration in patients with impaired growth hormone secretion
Journal Title: Archives of Medical Science - Year 2005, Vol 1, Issue 2
Abstract
There is a growing number of studies which have revealed that the growth hormone (GH) plays a role in regulation of systemic inflammatory response. Interleukin-6 (IL-6) is a well established pro-inflammatory, proangiogenic and adipocyte expressed cytokine that is also involved in pituitary tumors pathophysiology. In this study, using commercially available kits, we aimed to determine serum concentrations of IL-6, GH and IGF-1 in the following groups of age and sex matched patients expressing impaired growth hormone secretion: patients with active acromegaly (n=11), patients cured from acromegaly (n=14), patients exhibiting growth hormone deficiency (GHD) induced by pituitary tumors (n=12), patients with GHD unrelated to pituitary tumors (n=10) and control group of healthy volunteers (n=15). Concentrations of IL-6 were significantly higher in both GHD groups with reference to controls. Acromegalic patients revealed comparable to healthy subjects IL-6 concentrations. Using segmental regression applied to the group combined of all patients (n=62), a cut off point for GH=2.27 ng/ml was determined below which a negative correlation with IL-6 was confirmed (r=-0.56, p
Authors and Affiliations
Anna Biernacka, Marcin Dobaczewski, Hanna Ławnicka, Jolanta Kunert-Radek
Keywords
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