Interrelation between birth weight, body mass index, insulin resistance, C-Reactive Protein-hs, adiponectin and leptin in children (Age 10 to 20 years)
Journal Title: International Journal of Medical Research and Review - Year 2017, Vol 5, Issue 12
Abstract
Background: India is projected to have one of the largest populations of obese children over the next decade. Birth weight reflects maternal nutrition and fetal programming which may be a leading cause of obesity. Adipokines also play an important role in development of obesity, inflammation and insulin resistance. The aim of this study is to evaluate serum adiponectin, leptin in Indian school-going children in the age group of 10–20 years. This study also describes distribution of adipokines concentrations and examines the inter-relationship of adipokines with birth weight, body mass index (BMI), C - reactive protein high sensitive (CRP-hs), and insulin resistance (IR).Methods:A cross-sectional study involves a total of 200 school going children between the age group of 10-20 yrs. Fasting plasma glucose, insulin, adiponectin, leptin, CRP-hs, were measured for the school going children and birth weight was recorded.BMI was defined as weight (kg) divided by height (m) squared. Insulin resistance was assessed using the homeostasis model (HOMA-IR).Results:Children with higher BMI had higher birth weight and insulin. Obese children had lower adiponectin and higher leptin levels suggestive of an inverse association with adipokines. Children with higher BMI had lower glucose.Conclusion:Leptinan indicator of fat mass induces insulin resistance and inflammation. The derangement observed in all related parameters including insulin resistance, leptin, adiponectin and CRP-hs were due to high fat mass. However, the relationship of birth weight and adipokines needs further evaluation.
Authors and Affiliations
Ravi R Thakre, S. S. Naik
Keywords
Related Articles
- EP ID EP277621
- DOI 10.17511/ijmrr. 2017.i12.03
- Views 117
- Downloads 0
Clinical features, visual outcome and association with systemic diseasein patients with episleritis and scleritis. A study of 50 eyes
Introduction: Episcleritis and scleritis are inflammatory disorders which can have an acute presentation and are frequently encountered by primary care practitioners.Episcleritis is a benign, self-limited disease that re...
To study the clinicobacteriological profile and antibiotic susceptibility pattern of community acquired pyodermas
Background: Pyodermas are the pyogenic skin infection encountered in dermatologic clinic and is mainly caused by Staphylococci and Streptococci. Aim: To find out causative organisms in community acquired pyodermas and th...
Uterine Lipoleiomyoma
Uterine fibroids or leiomyomas are benign tumors of the uterine smooth muscle. A rare form of these tumors is uterine lipoleiomyoma - benign tumor consisting of a mixture of adipocytes and smooth muscle cells. Lipoleiomy...
Unusual presentation of interrupted aortic arch: a case report and radiological review
Interrupted aortic arch, a rare congenital malformation and there is a loss of luminal continuity between the ascending and descending portions of the aortic arch. Their incidences are of 3 per million live births and ma...
Drug Safety of Celecoxib
Introduction: Non-steroidal anti-inflammatory drugs presently are the most widely used drugs in medicine and are the most frequent cause of adverse drug reactions, affecting multiple systems, mainly gastric, renal & card...