Interrelation of Immunological and Clinic-Morphological Parameters in Patients with Chronic Hepatitis C Depending on Mixed Cryoglobulinemia
Journal Title: Актуальна інфектологія - Year 2016, Vol 2, Issue 11
Abstract
Introduction. Mixed cryoglobulinemia is the most common extrahepatic manifestations of chronic HCV-infection. Questions about the role of cytokines and features of liver injury in patients with chronic HCV-infection with mixed cryoglobulinemia are debatable. Objective. To determine the interrelation between changes of immunological parameters (cryoglobulins, interferon-gamma, interleukin‑4) and clinic-morphological parameters in patients with chronic hepatitis C with mixed cryoglobulinemia. Materials and methods. Eighty two patients with chronic hepatitis C were examined. Stage of liver fibrosis was determined by morphological study of hepatic samples. Concentration of interferon-gamma and nterleykin‑4 was determined by enzyme immunoassay. Cryoglobulin level was determined by spectrophotometry. Results. In patients with mixed cryoglobulinemia low levels of interferon gamma and high levels of interleukin‑4 were detected in serum, the correlation between concentration of cryoglobulins and interferon gamma (r = –0.32; p < 0.05) and interleukin‑4 (r = 0.36; p < 0.05) was found. The higher level of mixed cryoglobulins was in patients with liver fibrosis F3–4 (p < 0.05). The greater frequency of clinical signs of cryoglobulinemic syndrome was registered in patients with liver fibrosis F3–4. Increasing concentration of mixed cryoglobulins was associated with the appearance of cryoglobulinemic syndrome symptoms (severe general weakness, skin purpura, Raynaud's syndrome) and their number and the severity of liver fibrosis. Enhanced level of interleukin‑4 is associated with the appearance of general weakness, skin purpura, and severe liver fibrosis. Conclusions. Increased level of mixed cryoglobulins is associated with the appearance of cryoglobulinemic syndrome symptoms, their number and with liver fibrosis severity. Increased interleukin‑4 correlates with the concentration of cryoglobulins, and is associated with the appearance of clinical manifestations cryoglobulinemic syndrome and with liver fibrosis F3–4. To improve the diagnosis course of chronic hepatitis C it is important to determine the concentration of cryoglobulins and interleukin‑4.
Authors and Affiliations
O. P. Mashko, E. V. Riabokon, T. E. Onischenko, E. A. Furyk
Clinical Efficiency of Application of Intravenous Immunoglobulin in Pregnant Women with Intrauterine Infection
The problem of intrauterine infection (IUI) is still relevant today. Ineffective treatment of this pathology is associated with physiological decline of the immunity in these patients. We have proposed the additional use...
Analysis of the Species Composition of Bloodsucking Mosquitoes in Odessa Region
The paper presents an analysis of the species composition of bloodsucking mosquitoes collected in 2011–2012 by the specialist of the laboratory for epizootiology of especially dangerous infections in Kominternivske, Bere...
Impact of Industrial Pollutant on Immune and Metabolic Status of Healthy Children Aged 12–14 Years Old Living in Various Industrial Areas of Luhansk Region
The study of factors affecting the health status remains one of the most urgent medical and social areas, especially in a society that has not yet overcome the tendency to reduce the standard of living, due to demographi...
Features of acute tonsillitis in the servicemen depending on the season
The article deals with an analysis of the literature on acute tonsillitis in military personnel and presents own data on the features of the course of acute tonsillitis in the servicemen.
Incidence of pertussis in Lviv region
A retrospective epidemiological study on the incidence of pertussis among residents of Lviv region in 2005–2017 was conducted. Medical histories of 691 patients aged 1 month to 75 years hospitalized to Lviv Regional Infe...