Intestinal microbiota in liver diseases: current state of the problem
Journal Title: Сучасна гастроентерологія - Year 2019, Vol 0, Issue 3
Abstract
The article presents analysis of the recent literature data, the results of experimental and clinical studies on role of participation the intestinal microbiota in the pathogenesis of various liver diseases: viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, primary sclerosing cholangitis, liver cirrhosis and hepatocellular carcinoma. Particular attention is paid to increasing intestinal permeability, which creates conditions for bacterial translocation, activation of the systemic inflammatory response, increased hyperdynamic blood flow and deterioration of the functional state of the liver. As a striking example of the effect of intestinal microbiota on the state of the liver, data on small intestinal bacterial overgrowth syndrome (SIBR) are presented. There was a high incidence of SIBR in chronic liver diseases, a relationship between increased intestinal permeability and severity of impaired liver function, development and severity of hepatic encephalopathy, and the likelihood of spontaneous bacterial peritonitis. Role of intestinal microbiota in the development of bacterial complications in liver cirrhosis, especially spontaneous bacterial peritonitis, is discussed. It is shown that intestinal dysbiosis is involved in dysregulation of the cell death/regeneration balance that underlies carcinogenesis. It is concluded that it is reasonable to include drugs correcting the composition of intestinal microbiota in therapy of a number of liver diseases. The advantages of rifaximin administration have been outlined in the improvement of liver functional state at non-alcoholic steatohepatitis, hepatic encephalopathy by means of correcting the composition of the intestinal microbiome.
Authors and Affiliations
N. B. Gubergrits, N. V. Byelyayeva, E. V. Berezhna, A. Ye. Klochkov, P. G. Fomenko, A. V. Tsys
Keywords
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- EP ID EP616019
- DOI 10.30978/MG-2019-3-79
- Views 143
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