Intravenous amino acids in trimester isolated oligohydramnios
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 2
Abstract
to determine the efficacy of maternal administration of intravenous amino acid solution in improving amniotic fluid volume in cases of isolated oligohydramnios and to observe its impact on mode of delivery and neonatal outcome. Study design: A prospective case-series. Place and duration of study: Government medical collage latur from June 2013 to May, 2014. Methodology: forty two women with singleton pregnancy, well estabilished gestational age and clinically and sonographically proven isolated oligophydramnios in the third trimester before 36 weeks were administered amino acid solution intravenously after excluding case of premature rapture of membranes, congenital anamaly of fetus, maternal pulmonary, cardiovascular and hypertensive disorder, and severe placental insufficiency (raised S/D ratio). Pre-infusion and post-infusion amniotic fluid index (AFI) was measured and repeated weekly. Women were followed till delivery. Result: according to repeated measurement analysis of variance, mean pre-infusion AFI was 4.7 cm, mean one week ost-infusion AFI was 5.8 cm, mean two week post-infusion AFI was 6.2cm mean three week AFI was 6.3cm (p-value 0.029, significant) cesarean section became a predominant mode of delivery in this group without a firm evidence of associated fetal compromise. Conclusion: Amino acid infusion is an effective therapy for raising AFI in isolated oligohydraminos in this case series. Liberal use of cesarean section in this selected group should be carefully re-evaluated.
Authors and Affiliations
Anagha Jinturkar, Priti Bagade
Keywords
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