Introducing Genes With Significant Role in Migraine: An Interactomic Approach
Journal Title: Basic and Clinical Neuroscience - Year 2019, Vol 10, Issue 4
Abstract
Introduction: Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology. One of which is bioinformatics approach that could provide additional information related to the identified biomarkers. Methods: In this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. Through STRING database Plug-in in Cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. Based on centrality and action types (expression, activation, and inhibition) genes were screened. Results: Numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. Activation was dominate action relative to inhibition between the central genes. Conclusion: The finding indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control of migraine.
Authors and Affiliations
Mona Zamanian-Azodi, Mostafa Rezaei-Tavirani, Reza Mahmoud Robati
Keywords
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- EP ID EP664467
- DOI 10.32598/bcn.10.4.363
- Views 94
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