Investigating effect of chamomile hydroalcoholic extract on movement disorders in the animal model of Parkinson's disease
Journal Title: Journal of Herbal Drugs - Year 2016, Vol 7, Issue 1
Abstract
Background & Aim: Parkinson's disease (PD) is a kind of disorder in the nervous system, which is characterized with multiple movement disorders. Factors such as oxidative stress are the most important causes for the degeneration of dopaminergic neurons in the substantia nigra and occurrence of Parkinson's disease. Thus, medications that have antioxidant functions could be an interesting target for treating the movement disorders caused by Parkinson's disease. Chamomile is the natural source of antioxidants. Experimental: In this study, 50 adult male Wistar rats were randomly divided into control and Parkinson's groups with 10 rats along with 3 Parkinson's groups, which received chamomile extract by gastric gavage method and doses of 5, 10, and 50 mg/kg once per day for 14 days. Also, 8 μg of 6-hydroxydopamine (6-OHDA) neurotoxin in 2 μl saline containing 1% ascorbic acid was injected into medial forebrain bundle (MFB) of the left hemisphere of the brain of the rats to induce Parkinson's disease. Results were presented as mean ± SD, one-way analysis of variance, and Tukey's post-hoc test. Results: Following subcutaneous injection 2.5 mg/kg apomorphine 14 days after injury with 6-OHDA in MFB of left brain, animals were rotated 360 degrees to the right by 10 <rpm. Moreover, these rats showed a significant difference in movement tests (balancing, immobility, and step length) compared with the control group. Treatment of the Parkinson's animals using different doses of chamomile extract compared with the untreated group resulted in significant improvement in motor activities and the doses of 10 and 50 mg/kg had maximum therapeutic effects. Recommended applications/industries: Probably because of its strong antioxidant effect and interference with the activity of movement pathway receptors, chamomile extract can be used to improve and reduce the movement disorders of Parkinson's disease in addition to pharmacotherapy.
Authors and Affiliations
Shahrbanoo Alami Rostami; Maryam Rafieirad
Keywords
Related Articles
- EP ID EP23504
- DOI -
- Views 372
- Downloads 18
Phytochemical of essential oil of Stachys lavandulifolia Vahl. collected from a natural habitat in western Isfahan, Iran
Background & Aim: The Lamiaceae family is one of the largest and most distinctive families of flowering plants, with about 220 genera and almost 4000 species worldwide. The genus Stachys is one of the largest represen...
Effect of ultrasound on the production of Carvone as a secondary metabolite in callus derived from Bunium persicum Boiss
Background & Aim: Medicinal plants are most valuable and useful sources as productive factors of drugs. Production and extraction of secondary metabolites have a huge economical importance in recent years. Carvone is a c...
Study the ethnobotany of medicinal plants in Sirjan, Kerman province, Iran
Background & Aim: Since traditional knowledge is base of producing new herbals and other natural products, and old people of ancient cities know about characteristics of such herbals, therefore, death of such people will...
The effect of climatic conditions on the concentration of stevioside in Stevia production in different regions of Iran and optimization of stevioside extraction
Background & Aim: According to the increase in diseases such as diabetes and obesity, using of saccharose alternatives for producing of low-calorie and sugar-free alternatives, are taken into consideration of researchers...
Oleuropein content in olive leaves extract of sponge cake
Background & Aim: Oleuropein has pharmacologic properties and is the main component of olive leaves which is considered to be the most pharmacologic compounds of olive (Olea europaea L.). The aim of this work was to inve...