Investigating for Insulin Resistance and Type 2 Diabetes Mellitus in Obese Children
Journal Title: Turkish Journal of Endocrinology and Metabolism - Year 2005, Vol 9, Issue 1
Abstract
The incidence and prevalence of type 2 diabetes mellitus within the childhood period has increased in the worldwide, particularly among obese children. The aim of this study was to investigate impaired glucose tolerance and insulin resistance in obese children. Thirty-six children (18 girls and 18 boys) aged between 7.4 and 17 years with a body mass index (BMI) > 95th percentile and referred to our hospital between 1998 and 2003. Control group consisted of 30 children (13 girls and 17 boys) aged between 7.2 and 17.8 years with a body mass index between 5th and 95th percentile. Fasting and oral glucose tolerance test (OGTT) 120th min serum glucose and insulin levels were measured. The glucose results were characterized according to the World Health Organizations criteria. Insulin resistance (IR) was defined by homeostasis model assessment (HOMA) as IRHOMA. Fasting glucose levels were in normal limits in all obese and control subjects. OGTT revealed that 9 of 36 obese children (25 %) had diagnosed impaired glucose tolerance and 2 children (6%) diabetes mellitus. Plasma glucose levels in OGTT were in normal limits in all control subjects. IRHOMA revealed insulin resistance in 17 of 36 obese children (47%) and significantly correlated puberty (r=0.418, p=0.0217), BMI (r=0.507, p=0.002), age (r=0.513, p=0.001), and insulin level at 120th min of OGTT (r=0.821, p<0.001). Overall mean IRHOMA in obese and control subjects were 4,1 ± 1.0 and 1,5 ± 0.9 , respectively. The difference of mean IRHOMA levels between obese and control subjects was significantly different (p<0,001). IRHOMA levels of 5 control subjects (16%) were above the level of cut-off point (2,5), however OGTT were normal in these subjects. In conclusion, the childhood obesity is one of the important risk factors for the early beginning of type 2 diabetes mellitus. An OGTT is more sensitive at identifying impaired glucose tolerance or diabetes mellitus than fasting glucose alone. Body-mass index (BMI) was strongest predictor of fasting and glucose stimulated insulin levels.
Authors and Affiliations
Enver Şimşek, Meltem Karabay, Şükrü Aras, Kenan Kocabay
Keywords
Related Articles
- EP ID EP84399
- DOI -
- Views 130
- Downloads 0
Electrophysiological Changes in Patients with Impaired Glucose Tolerance
The effect of impaired glucose tolerance on neuropathy is not well characterized. This study is performed to clarify the status of peripheral neuropathy in patients with impaired glucose tolerance with no symptoms of neu...
Editörden
Turner Syndrome; A Case Report With Growth Failure
Turner syndrome which afflicts approximately 50 per 100000 females is characterized by retarded growth, gonadal dysgenesis, and infertility. Growth failure is a consistent finding at birth in infants with Turner's syndro...
The Effects of Hyperthyroidism on Lipid Peroxidation, Erythrocyte Glutathione and Glutathione Peroxidase
Previous studies have suggested that hyperthyroidism has some effects on lipid peroxidation and antioxidant systems. This study was designed to determine if lipid peroxid ation, glutathione, and glutathione peroxidase ca...
Thyrotropin Receptor Antibody Levels in Patients with Autoimmune Thyroid Disease in Iodine Deficient Areas
In this study, we investigated Thyrotropin Receptor Antibody (TRab) levels in Hashimoto and Graves' diseases. A total of 189 patients and 25 controls were assessed, retrospectively. Fifty-four of the 189 patients had eut...