INVESTIGATION OF ACUTE TOXICITY AND ANTI-EXUDATIVE ACTIVITY OF DERIVATIVES OF YLIDENE HYDRAZIDES 8-PIPERIDINOTOOFILINYL-7-ACETIC ACID
Journal Title: Молодий вчений - Year 2018, Vol 5, Issue 57
Abstract
It is determined that LD50 of derivatives of 8-piperidinotoofilinyl-7-acetic acid are in the interval from 320 to 540 mg/kg. The dependence of anti-exudative activity from a chemical structure of derivatives of 8-piperidinotoofilinyl-7-acetic acid is tested for rats. It is established that the compound 1-5-nitrofuril- 2-propenilidehrazid-8-pyperidinoteopnilin-7-acetic acid shown the most anti-exudative activity which was reducing carrageenan edema of rats by 36,7% and didn’t yield in activity to comparative drug as diclofenac sodium. The derivatives of ylidene hydrazides 8-piperidinotoofilinyl-7-acetic acid are a perspective group of organic substances for performance of streamlined synthesis and pharmacological screening with a view to develop the new non-steroidal anti-inflammatory medicine based on them.
Authors and Affiliations
K. A. Duchenko, V. I. Korniienko, O. V. Ladohubets, I. V. Harkusha
Keywords
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