INVESTIGATION OF INFLUENCE OF INTRADERMAL IMMUNIZATION WITH INACTIVATED AUTOLEUKOCYTES ON THE CONDITION OF ANTIVIRAL IMMUNITY IN PATIENTS WITH CHRONIC HEPATITIS B
Journal Title: Гепатологія - Year 2016, Vol 32, Issue 2
Abstract
Data about infl uence of autoleukocyte immunization with inactivated autoleukocytes on the condition of delayed-type hypersensitivity in relation to HBV antigens have been presented in the article. Th e investigation was conducted in leukocyte cultures, prepared from venous blood cells of patients with chronic hepatitis B. Stimulating antigen (НВsAg) on solid phase was added to leukocyte culture. Infl uence of antigen on delayed-type hypersensitivity phenomenon was evaluated by the leukocyte synthesis of tumor necrosis factor alpha. Leukocyte culture was prepared from blood cells, obtained before and in 10 days aft er immunization of patients with autoleukocytes. It has been established that delayed-type hypersensitivity phenomenon to virus, as a rule, is slightly evident in patients with chronic hepatitis B. However, it signifi cantly increases aft er intradermal autoleukocyte immunization. It is impossible to evaluate the effi cacy of immunity in patients only by these data. However, it is confi rmed that antiviral immunity intensifi es.
Authors and Affiliations
O Herasun
Keywords
Related Articles
- EP ID EP250359
- DOI -
- Views 114
- Downloads 0
COGNITIVE AND PSYCHOLOGICAL DISTURBANCES IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B AND C
Cognitive impairments mainly of mild degree have been established during standard neuropsychological testing of patients with chronic viral hepatitis. However, patients who received antiviral interferon therap...
NON-ALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CONCOMITANT ARTERIAL
Examination data of patients with type 2 diabetes mellitus and arterial hyper- tension and revealed condition of detoxifying liver function using a 13 C-methacetin test have been analyzed in the article. Trea...
Клініко-лабораторні особливості синдрому жовтяниці у дітей
The article presents the research results of basic biochemical indices of 79 children with jaundice syndrome of various genesis who were hospitalized with an initial diagnosis of “viral hepatitis”. Viral hepatitis was co...
EPIDEMIOLOGY OF HEPATITIS Е
Peculiarities of epidemiology of hepatitis E in the world (literature review) and results of own investigations of identifi cation of antibodies against hepatitis E virus among the population of the Russian Federation...
MINERAL HOMEOSTASIS IN FUNCTIONAL DISORDERS OF THE LIVER IN SOLDIERS OF ANTITERRORIST OPERATION WITH BRAIN INJURY OF MILD AND MODERATE SEVERITY
Th e article is dedicated to the study of interconnection of brain metabolism impairment in craniocerebral injury of mild and moderate severity in soldiers of antiterrorist operation with changes...